{"id":"W4379160884","doi":"10.1158/1538-7445.prca2023-b073","title":"Abstract B073: Inhibiting prostate cancer by targeting the metabolic mevalonate pathway","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Mevalonate pathway; LNCaP; Statin; Prostate cancer; Medicine; Pharmacology; Cancer research; Fluvastatin; Cholesterol; Cancer; Sterol regulatory element-binding protein; Biology; Simvastatin; Internal medicine; Biosynthesis; Sterol; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001647624,0.0004730072,0.0004337574,0.000476934,0.0001658771,0.0004760167,0.0003352753,0.0004194589,0.002980535],"category_scores_gemma":[0.0001044461,0.000198212,0.00048112,0.000336297,0.0001677719,0.0001620435,0.0001857774,0.0005940347,0.001031215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000458062,"about_ca_system_score_gemma":0.0006084577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001874525,"about_ca_topic_score_gemma":0.002747882,"domain_scores_codex":[0.9998947,0.0000144429,0.000006211231,0.00002015047,0.00004503144,0.00001944676],"domain_scores_gemma":[0.9999501,0.000008026547,0.00001151246,0.000004077918,0.00001330571,0.00001298367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005770097,0.0002252423,0.0004689177,0.0003417527,0.00006248505,0.00006910603,0.000008563386,0.002141866,0.9793833,0.0003694175,0.0009934764,0.01535895],"study_design_scores_gemma":[0.0002171569,0.002419927,0.003741248,0.00004000308,0.000163399,0.0003286037,0.0000231502,0.01185444,0.9623718,0.0002114412,0.01859866,0.00003013981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9451818,0.01723352,0.01480035,0.0009147557,0.0002074316,0.0004193033,0.006534338,0.001096791,0.01361169],"genre_scores_gemma":[0.9586192,0.008305557,0.01925733,0.0005652663,0.00002713019,0.0001554137,0.006074679,0.0001070124,0.006888498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002980535,"threshold_uncertainty_score":0.009970844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0384296705726298,"score_gpt":0.3637459443858833,"score_spread":0.3253162738132535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}