{"id":"W4379162225","doi":"10.7554/elife.87989","title":"Binding to nucleosome poises human SIRT6 for histone H3 deacetylation","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"French Infrastructure for Integrated Structural Biology; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Grand Équipement National De Calcul Intensif; Agence Nationale de la Recherche","keywords":"Nucleosome; Histone octamer; Histone; Histone H3; Histone code; Linker DNA; Histone methylation; Cell biology; Chemistry; Chromatosome; Biology; Biophysics; Biochemistry; DNA; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007413963,0.0001901573,0.0002422765,0.00005041054,0.0003725077,0.0003330126,0.000351638,0.0004260795,0.003471561],"category_scores_gemma":[0.0001826381,0.0002370067,0.0003363109,0.00008117197,0.0002281153,0.0002758674,0.0002672603,0.0004415984,0.0007180278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005321968,"about_ca_system_score_gemma":0.0003890794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007910161,"about_ca_topic_score_gemma":0.008270738,"domain_scores_codex":[0.9999501,0.000005253246,0.000001298072,0.00001428147,0.00001770892,0.00001131852],"domain_scores_gemma":[0.9999598,0.000007731928,0.000007329405,0.000007307852,0.000007039873,0.00001084804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006310607,0.0001182337,0.0137655,0.0002551642,0.0001564275,0.0006697763,0.0004460628,0.1197667,0.8383547,0.008153093,0.002578272,0.01510511],"study_design_scores_gemma":[0.00023731,0.0004376945,0.02947854,0.00008057395,0.0001108909,0.0008546805,0.0004378786,0.4300048,0.4946156,0.00573397,0.03788383,0.0001241982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712648,0.00111176,0.01936654,0.0002490174,0.000050887,0.00001142891,0.0004168971,0.0003164192,0.007212238],"genre_scores_gemma":[0.9863366,0.0005177904,0.009534733,0.00008443376,0.000006598936,0.000008401652,0.000786541,0.00008819331,0.002636876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007910161,"threshold_uncertainty_score":0.01572824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05491618364165594,"score_gpt":0.4087262931999888,"score_spread":0.3538101095583328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}