{"id":"W4379184638","doi":"10.1007/s13311-023-01393-1","title":"Axonal Transport Defect in Gigaxonin Deficiency Rescued by Tubastatin A","year":2023,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Axoplasmic transport; Peripherin; HDAC6; Cell biology; Neurofilament; Biology; Organelle; Genetically modified mouse; Neuroscience; Proteasome; Transgene; Histone deacetylase; Chemistry; Histone; Biochemistry; Immunohistochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003185821,0.0001496089,0.0001284901,0.00009517354,0.00005861546,0.00001085932,0.000243639,0.0001663018,0.00004423673],"category_scores_gemma":[0.00003018843,0.0001440365,0.0001030716,0.0003931434,0.000118645,0.000001910845,0.00002954633,0.0001941502,0.00006205826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008517368,"about_ca_system_score_gemma":0.00008275727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001600328,"about_ca_topic_score_gemma":0.00005162724,"domain_scores_codex":[0.998625,0.0001471124,0.000200513,0.0004014157,0.0001773904,0.0004485072],"domain_scores_gemma":[0.9995689,0.0000303966,0.00002695005,0.0002781071,0.00002893398,0.00006665148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000139723,0.00009993012,0.04470616,0.00001446036,0.00001842343,0.00006857266,0.00006737133,0.00003640259,0.9484671,0.00005528719,0.001816155,0.004510453],"study_design_scores_gemma":[0.00411451,0.002050455,0.07498278,0.0000300039,0.00003356979,0.0001629159,0.0002804774,0.0009076048,0.6022748,0.0003056815,0.3139139,0.0009433686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966444,0.0007416723,0.0003254119,0.0002718264,0.00008746773,0.0002445413,0.00003936373,0.0000367481,0.001608598],"genre_scores_gemma":[0.9966132,0.0005610953,0.0000696096,0.0005655275,0.00004877729,0.00005107866,0.0002314382,0.00003752033,0.001821719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3461923,"threshold_uncertainty_score":0.5873637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213742426014327,"score_gpt":0.290568128026333,"score_spread":0.2684307037661898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}