{"id":"W4379184638","doi":"10.1007/s13311-023-01393-1","title":"Axonal Transport Defect in Gigaxonin Deficiency Rescued by Tubastatin A","year":2023,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Axoplasmic transport; Peripherin; HDAC6; Cell biology; Neurofilament; Biology; Organelle; Genetically modified mouse; Neuroscience; Proteasome; Transgene; Histone deacetylase; Chemistry; Histone; Biochemistry; Immunohistochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008065523,0.000581331,0.0004166728,0.0003056999,0.0001815114,0.0002303217,0.0002355574,0.0004195997,0.001024401],"category_scores_gemma":[0.00007129836,0.00018185,0.0004632816,0.0001677393,0.000294242,0.0001954262,0.0002072116,0.0007021604,0.0003070725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002816412,"about_ca_system_score_gemma":0.0001877206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046898,"about_ca_topic_score_gemma":0.001243827,"domain_scores_codex":[0.9998978,0.00001257489,0.0000199991,0.00002806057,0.00002146408,0.00002007048],"domain_scores_gemma":[0.9998835,0.000009508339,0.00004417327,0.000009254797,0.000007339988,0.00004606845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009246649,0.00002277174,0.0001345997,0.00003104958,0.00000534536,0.0001581077,0.000008380977,0.00003395465,0.9990741,0.00002934732,0.00001696045,0.0003929058],"study_design_scores_gemma":[0.00007548695,0.001016058,0.01153276,0.00001861376,0.00006363389,0.002127962,0.00008323783,0.001175225,0.9810743,0.00008360338,0.002735683,0.00001355319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969453,0.000606246,0.001155375,0.00006837868,0.00003013065,0.00002780975,0.0004057813,0.0001100153,0.0006509081],"genre_scores_gemma":[0.9943622,0.0008605063,0.001536018,0.00005233537,0.00000959061,0.00004890131,0.0006089862,0.0000400678,0.002481393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046898,"threshold_uncertainty_score":0.003426969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213742426014327,"score_gpt":0.290568128026333,"score_spread":0.2684307037661898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}