{"id":"W4379193122","doi":"10.1101/2023.05.31.542915","title":"TPPP Forms Liquid Condensates and Aggregates in Multiple System Atrophy","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Microtubule; Cell biology; Golgi apparatus; Chemistry; Biophysics; Biology; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001390574,0.0002467278,0.0002649243,0.0004918777,0.0002219192,0.0003931246,0.00008419451,0.0002548251,0.001089303],"category_scores_gemma":[0.0001560387,0.0001597452,0.0001885785,0.0002278531,0.0002950553,0.0002042322,0.0003133624,0.0003537383,0.0004094326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002691387,"about_ca_system_score_gemma":0.0001243167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006987855,"about_ca_topic_score_gemma":0.000586894,"domain_scores_codex":[0.9999106,0.00001280803,0.000007124544,0.00001896363,0.00003243458,0.00001801392],"domain_scores_gemma":[0.9998239,0.0000238108,0.00007359923,0.00001504581,0.00002208806,0.00004160859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009420316,0.00001859377,0.001477399,0.00002235111,0.00001355389,0.0005985945,0.00004957562,0.0001544709,0.9961403,0.0002259875,0.00008457083,0.001120409],"study_design_scores_gemma":[0.00002213637,0.0003213948,0.02435248,0.000009518372,0.00003305886,0.002815337,0.0001009831,0.003914225,0.9649186,0.0006901797,0.002812578,0.000009595523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951827,0.0009902656,0.002768708,0.00005481781,0.00001335292,0.00001133142,0.00009975161,0.00007572653,0.0008032538],"genre_scores_gemma":[0.9973119,0.0003446497,0.0007676495,0.00002218491,0.000009755892,0.000008267401,0.0001922928,0.00002440314,0.001318895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001089303,"threshold_uncertainty_score":0.003644109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01626232341104696,"score_gpt":0.2312041261837806,"score_spread":0.2149418027727336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}