{"id":"W4379230501","doi":"10.3390/curroncol30060410","title":"Biomarkers for Predicting Anti-Programmed Cell Death-1 Antibody Treatment Effects in Head and Neck Cancer","year":2023,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science","keywords":"Medicine; Internal medicine; Oncology; Head and neck cancer; Head and neck squamous-cell carcinoma; Biomarker; Antibody; Cancer; Multivariate analysis; Performance status; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000900391,0.0003856025,0.0005620937,0.001043661,0.0001742151,0.000495668,0.0002319114,0.000388228,0.0004239375],"category_scores_gemma":[0.002288268,0.0001705201,0.0002749683,0.0008318765,0.0002037135,0.0002990208,0.000293433,0.0004065322,0.0001249215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002676035,"about_ca_system_score_gemma":0.0001754827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007166892,"about_ca_topic_score_gemma":0.00107789,"domain_scores_codex":[0.9996387,0.0001425353,0.0000599991,0.00006071266,0.00006637648,0.00003174699],"domain_scores_gemma":[0.9985832,0.0003797902,0.0007562242,0.00005511544,0.0001344418,0.00009122775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000600339,0.00007271924,0.9814212,0.00005535323,0.0001249615,0.00007849316,0.0000430929,0.0007177333,0.003220041,0.0000236101,0.0001087845,0.0135338],"study_design_scores_gemma":[0.00003844778,0.0005808513,0.9933926,0.00002429431,0.0001157979,0.0003881752,0.0001012582,0.002688886,0.002055813,0.0001338546,0.0004652956,0.00001462255],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973425,0.001776764,0.0004001455,0.00003963349,0.000009434343,0.00002002327,0.0001929319,0.000009869546,0.0002087759],"genre_scores_gemma":[0.9987318,0.0002830051,0.0006274651,0.00002642817,0.000009701123,0.00001493169,0.0002107454,0.000001355203,0.00009462819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001043661,"threshold_uncertainty_score":0.004761755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09162956156182502,"score_gpt":0.4393964561776715,"score_spread":0.3477668946158465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}