{"id":"W4379232529","doi":"10.3390/curroncol30060411","title":"HR+/HER2– Advanced Breast Cancer Treatment in the First-Line Setting: Expert Review","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of British Columbia; Dr. H. Bliss Murphy Cancer Centre; Sunnybrook Health Science Centre; McGill University Health Centre; Mount Sinai Hospital","funders":"Novartis Pharmaceuticals Canada; Astellas Pharma; Mylan; Genomic Health; Seagen; Gilead Sciences; Sanofi; Amgen; Pfizer; Myriad Genetics; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Palbociclib; Fulvestrant; Oncology; Internal medicine; Breast cancer; Cancer; Disease; Metastatic breast cancer; Bevacizumab; Life expectancy; Intensive care medicine; Tamoxifen; Population; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004881073,0.0009021397,0.004001989,0.0002597808,0.0001074147,0.00001199347,0.0005187531,0.0003375724,0.0003782249],"category_scores_gemma":[0.0001049013,0.0005195091,0.0007940526,0.001044037,0.0001859208,0.00007193269,0.0001192843,0.0009321308,0.0002443024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003479972,"about_ca_system_score_gemma":0.001585574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007691125,"about_ca_topic_score_gemma":0.000424692,"domain_scores_codex":[0.9961488,0.0004462306,0.001296849,0.000933635,0.0003924511,0.0007820713],"domain_scores_gemma":[0.9972617,0.0006701743,0.0007527573,0.001011693,0.0001398476,0.0001638376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006877026,0.0006128764,0.00002917708,0.04045084,0.0002505599,0.0001490924,0.0003205888,0.000001571084,8.457811e-8,0.00001590402,0.003478185,0.9546223],"study_design_scores_gemma":[0.00163073,0.0004004914,0.00006693786,0.1276812,0.001207872,0.0007883164,0.00006108562,0.000002502831,1.323819e-7,0.00002687904,0.8677618,0.000372048],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002411287,0.9824121,0.00001301813,0.0097232,0.002216222,0.004972329,0.0002882096,0.0001580041,0.0002145301],"genre_scores_gemma":[0.00000115138,0.9851329,0.00009512166,0.001568473,0.001952896,0.0103094,0.0004298359,0.0001591443,0.0003511178],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9542503,"threshold_uncertainty_score":0.9997256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2135830166260177,"score_gpt":0.5293600720080169,"score_spread":0.3157770553819992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}