{"id":"W4379233035","doi":"10.3389/fncel.2023.1184563","title":"Homeostatic regulation of neuronal function: importance of degeneracy and pleiotropy","year":2023,"lang":"en","type":"review","venue":"Frontiers in Cellular Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Degeneracy (biology); Pleiotropy; Homeostatic plasticity; Homeostasis; Neuroscience; Function (biology); Biology; Negative feedback; Bioinformatics; Cell biology; Physics; Genetics; Gene; Phenotype; Receptor; Neurotransmission","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007376448,0.0004911113,0.001568327,0.001109088,0.0001938681,0.00005493878,0.001275642,0.0001927339,0.00001503957],"category_scores_gemma":[0.001485377,0.000452582,0.0002568469,0.004398741,0.001989606,0.0004267191,0.0005052797,0.0007761025,0.000008873297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005569707,"about_ca_system_score_gemma":0.0004757529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003866414,"about_ca_topic_score_gemma":0.000001009369,"domain_scores_codex":[0.9942139,0.0009153879,0.001352381,0.001672777,0.001100455,0.0007451466],"domain_scores_gemma":[0.9973896,0.0006632497,0.0009847198,0.000704273,0.00005928571,0.0001988756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001570393,0.0004652907,0.002717847,0.01805315,0.00001132168,0.000662144,0.000115448,0.0001811646,0.7988446,0.00111553,0.001955996,0.1757205],"study_design_scores_gemma":[0.00324011,0.003943264,0.005319724,0.008643473,0.0009986092,0.000544616,0.00008808881,0.01884533,0.3082727,0.004348991,0.6420456,0.003709481],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05676035,0.9310355,0.001424693,0.00007864074,0.007549359,0.002695929,0.0001996604,0.0001411346,0.0001147005],"genre_scores_gemma":[0.00723843,0.9916043,0.0001199351,0.0001653903,0.00006048667,0.00006903878,0.00000363277,0.00008551976,0.0006532259],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6400896,"threshold_uncertainty_score":0.9997926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1045366129700106,"score_gpt":0.357309537309898,"score_spread":0.2527729243398874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}