{"id":"W4379233486","doi":"10.1016/j.crmeth.2023.100489","title":"Optical opening of the blood-brain barrier for targeted and ultra-sparse viral infection of cells in mouse cortex","year":2023,"lang":"en","type":"article","venue":"Cell Reports Methods","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Optogenetics; Recombinase; Viral vector; Neuroscience; Channelrhodopsin; Cortex (anatomy); Biomedical engineering; Transduction (biophysics); Medicine; Biology; Cell biology; Recombinant DNA; Biophysics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004328518,0.0005811963,0.0003217158,0.0005516925,0.000284848,0.0005583889,0.0005482137,0.0005798316,0.001208394],"category_scores_gemma":[0.0002171625,0.0003505744,0.0004366306,0.0001818814,0.0004782353,0.0004863571,0.0005117221,0.001276283,0.0004126116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004431016,"about_ca_system_score_gemma":0.0006620602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008735816,"about_ca_topic_score_gemma":0.001635629,"domain_scores_codex":[0.9996666,0.00003034822,0.00002218871,0.00009901129,0.00009183038,0.00008999043],"domain_scores_gemma":[0.9997661,0.00004418384,0.00008386995,0.00003207283,0.00001918553,0.00005457407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003529927,0.00002021765,0.00003833966,0.00002126977,0.000002563507,0.00002521376,0.0000155818,0.00006471802,0.9986065,0.0002759487,0.00002678307,0.0008674218],"study_design_scores_gemma":[0.00001451018,0.0001488367,0.000746418,0.000008657315,0.00000835473,0.0001364014,0.00001510236,0.0009185105,0.9966883,0.00009698393,0.001213765,0.000004188501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8951896,0.003063151,0.09515206,0.0004616244,0.000173666,0.0003072304,0.0007706796,0.0007823855,0.0040997],"genre_scores_gemma":[0.9310992,0.002631641,0.05878602,0.0001388575,0.00003371831,0.0004921969,0.0004584595,0.0001913153,0.006168559],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001208394,"threshold_uncertainty_score":0.004042506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05483641612017244,"score_gpt":0.3771227247720635,"score_spread":0.3222863086518911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}