{"id":"W4379233486","doi":"10.1016/j.crmeth.2023.100489","title":"Optical opening of the blood-brain barrier for targeted and ultra-sparse viral infection of cells in mouse cortex","year":2023,"lang":"en","type":"article","venue":"Cell Reports Methods","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Optogenetics; Recombinase; Viral vector; Neuroscience; Channelrhodopsin; Cortex (anatomy); Biomedical engineering; Transduction (biophysics); Medicine; Biology; Cell biology; Recombinant DNA; Biophysics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002446593,0.0001054005,0.0002398521,0.000155362,0.00006952164,0.00002034519,0.0001326721,0.0000915475,0.00002505505],"category_scores_gemma":[0.003427246,0.00008238004,0.00009141993,0.0005120075,0.0002300447,0.00005537671,0.0001184141,0.0001741474,4.814468e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001389491,"about_ca_system_score_gemma":0.00009257128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006580764,"about_ca_topic_score_gemma":0.000005723474,"domain_scores_codex":[0.9981682,0.0004691535,0.0004666469,0.0003573381,0.0002671057,0.0002715289],"domain_scores_gemma":[0.9980915,0.001236965,0.000192918,0.0003356728,0.00005758776,0.0000854199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002612747,0.00005317985,0.005112271,0.00006963841,0.000003114648,0.00001459501,0.000244226,0.0002496272,0.9931775,0.0000288812,0.00006127857,0.0009595156],"study_design_scores_gemma":[0.00027098,0.00009882263,0.004897233,0.00001305422,0.00001146594,0.00001343009,0.00001974327,0.001764578,0.991795,0.0003195211,0.0007131242,0.00008303621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965762,0.00002075158,0.001518743,0.00001548432,0.0003301651,0.0005746886,0.0000149049,0.00001767888,0.0009314132],"genre_scores_gemma":[0.9889125,0.00006769792,0.009191876,0.00002799841,0.00001659824,0.00004245846,0.000001875052,0.00002173373,0.00171726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007673133,"threshold_uncertainty_score":0.4102981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05483641612017244,"score_gpt":0.3771227247720635,"score_spread":0.3222863086518911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}