{"id":"W4379276529","doi":"10.1016/j.omtn.2023.05.012","title":"All roads lead to cure: Diversity of oligonucleotides in DM1 therapy","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Narodowym Centrum Nauki; Narodowe Centrum Nauki; Agencja Badań Medycznych; Canadian Association of Gastroenterology","keywords":"RNA; Oligonucleotide; Computational biology; RNase H; microRNA; Biology; Messenger RNA; Genetics; DNA; Nucleic acid; RNase P; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006607147,0.0002451922,0.0003674625,0.0005140197,0.00023402,0.0007733635,0.0002748013,0.0005156172,0.003055911],"category_scores_gemma":[0.0004443389,0.0001069654,0.0002334014,0.0002765684,0.0005001036,0.0008755157,0.0005958016,0.001532767,0.0006355331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004657457,"about_ca_system_score_gemma":0.0003409695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002689412,"about_ca_topic_score_gemma":0.0009971443,"domain_scores_codex":[0.9998237,0.00006019213,0.000009837272,0.0000324698,0.00004865089,0.00002513269],"domain_scores_gemma":[0.9998667,0.00005090486,0.00001915989,0.000009902701,0.00002350256,0.00002981748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006902499,0.0003275299,0.001014708,0.001347959,0.0001037815,0.0003783333,0.0002659899,0.001656208,0.1263297,0.04050864,0.01245981,0.814917],"study_design_scores_gemma":[0.0003426054,0.003890111,0.003151995,0.001287023,0.0002336889,0.002685896,0.0003255098,0.002114735,0.08471987,0.04117153,0.8600029,0.00007415582],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08657967,0.7961178,0.03873295,0.03043495,0.002564321,0.0001867863,0.0003741289,0.0003140903,0.04469537],"genre_scores_gemma":[0.4618224,0.4687698,0.03324908,0.01182202,0.001456603,0.0002974397,0.0003094515,0.0001432863,0.02212994],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003055911,"threshold_uncertainty_score":0.01022303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04936872590522342,"score_gpt":0.2866032204460993,"score_spread":0.2372344945408758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}