{"id":"W4379276580","doi":"10.33380/2305-2066-2023-12-2-190-197","title":"Development and Validation of the ELISA Method for Neutralizing Anti-trastuzumab Antibodies Detection in Human Blood Serum","year":2023,"lang":"en","type":"article","venue":"Drug development & registration","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Public Health Association","funders":"","keywords":"Trastuzumab; Medicine; Immunogenicity; Antibody; Bioequivalence; Gold standard (test); Pharmacology; Cancer; Immunology; Internal medicine; Breast cancer; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000987376,0.0001538399,0.0002426178,0.0002264949,0.0003133675,0.00003234823,0.00008392449,0.00006818409,0.000005754207],"category_scores_gemma":[0.00006182096,0.0001182012,0.00005136777,0.0004153772,0.00005654127,0.0001089971,0.00006060298,0.0001302786,0.000002454288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007266601,"about_ca_system_score_gemma":0.0002267648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008769129,"about_ca_topic_score_gemma":0.0003904336,"domain_scores_codex":[0.9984713,0.0000691182,0.0005227587,0.0002823408,0.0003906886,0.0002638339],"domain_scores_gemma":[0.9994636,0.00007581992,0.0001610238,0.000130828,0.0001178401,0.0000508973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001716794,0.0002421667,0.1133466,0.001464601,0.000163997,0.00001263568,0.009779014,0.0001130462,0.8069083,0.001376547,0.0002560235,0.06616535],"study_design_scores_gemma":[0.0005838187,0.00002643123,0.3689494,0.0001578154,0.00002112224,0.00001233068,0.0004394527,0.0002380019,0.625495,0.00008604299,0.003893357,0.00009721957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973195,0.00005561838,0.0006473614,0.0008190339,0.00008861841,0.0007497754,0.000005070333,0.00004070486,0.0002743398],"genre_scores_gemma":[0.9849771,0.00005371771,0.01306398,0.00003289305,0.00004733293,0.00008414968,0.0001284652,0.00001541053,0.001597001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2556028,"threshold_uncertainty_score":0.4820105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04488240243248364,"score_gpt":0.3468475382783933,"score_spread":0.3019651358459096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}