{"id":"W4379280923","doi":"10.1200/jco.2023.41.16_suppl.tps9144","title":"KontRASt-02: A phase III trial investigating the efficacy and safety of the KRAS <sup>G12C</sup> inhibitor JDQ443 vs docetaxel in patients with previously treated, locally advanced or metastatic, <i>KRAS G12C</i> -mutated NSCLC.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System; University of Toronto","funders":"Novartis Pharmaceuticals Corporation","keywords":"KRAS; Docetaxel; Medicine; Oncology; Internal medicine; Chemotherapy; Cancer; Context (archaeology); Lung cancer; Cancer research; Colorectal cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002600536,0.0002605674,0.001125715,0.00006858908,0.0001054796,0.0000207175,0.0003827301,0.0002566083,0.00001340878],"category_scores_gemma":[0.001802735,0.0001279307,0.0002798447,0.0003852239,0.0004390524,0.00001758582,0.0001578972,0.0006037929,0.000001077264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004866029,"about_ca_system_score_gemma":0.001279573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000227061,"about_ca_topic_score_gemma":0.0001729524,"domain_scores_codex":[0.9959642,0.0008290933,0.00213748,0.0003275309,0.0003756515,0.0003659952],"domain_scores_gemma":[0.9964019,0.0009408533,0.001765684,0.0003173897,0.0003546439,0.000219515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6346546,0.005181749,0.005942496,0.00009564674,0.0019692,0.0001135002,0.001153367,0.003091453,0.03004826,0.0001074109,0.001034088,0.3166082],"study_design_scores_gemma":[0.801536,0.1165551,0.01526481,0.0007792547,0.001562473,0.00009420414,0.0008652348,0.001145954,0.02386523,0.0004460249,0.03717258,0.0007131649],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966637,0.0002724853,0.0002148547,0.001150797,0.000395707,0.001212936,0.00002837282,0.000006306315,0.00005477174],"genre_scores_gemma":[0.9966854,0.0007629818,0.0005975176,0.001411995,0.0003757047,0.0000260977,0.00001778017,0.00003261092,0.0000898942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3158951,"threshold_uncertainty_score":0.5216861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04660133977478886,"score_gpt":0.3800885671347362,"score_spread":0.3334872273599473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}