{"id":"W4379280923","doi":"10.1200/jco.2023.41.16_suppl.tps9144","title":"KontRASt-02: A phase III trial investigating the efficacy and safety of the KRAS <sup>G12C</sup> inhibitor JDQ443 vs docetaxel in patients with previously treated, locally advanced or metastatic, <i>KRAS G12C</i> -mutated NSCLC.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System; University of Toronto","funders":"Novartis Pharmaceuticals Corporation","keywords":"KRAS; Docetaxel; Medicine; Oncology; Internal medicine; Chemotherapy; Cancer; Context (archaeology); Lung cancer; Cancer research; Colorectal cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001064352,0.001575872,0.001409064,0.0003522245,0.0003424782,0.001473002,0.001160941,0.001424462,0.007438114],"category_scores_gemma":[0.0007636892,0.0005126235,0.00166758,0.0004743214,0.0008328524,0.001076334,0.0003793296,0.003910467,0.001562735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001149368,"about_ca_system_score_gemma":0.001744077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001495295,"about_ca_topic_score_gemma":0.005120177,"domain_scores_codex":[0.9997512,0.00009413042,0.00001332306,0.00005534677,0.00002633273,0.00005962628],"domain_scores_gemma":[0.9994797,0.00006858744,0.000124932,0.00003257242,0.00003516365,0.0002590737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7651494,0.04524295,0.004459462,0.002630608,0.002745602,0.0003548891,0.0003787321,0.005373037,0.03837503,0.000726628,0.01220456,0.1223591],"study_design_scores_gemma":[0.5920386,0.3893901,0.006226308,0.0001157924,0.0008712038,0.0005569949,0.0001442064,0.001939052,0.003285095,0.0004257222,0.004956248,0.00005074541],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796702,0.006173139,0.0009106557,0.001016656,0.0003762442,0.002671974,0.004075142,0.0004031102,0.004702902],"genre_scores_gemma":[0.9772776,0.004653264,0.001482399,0.001382474,0.000188199,0.002294162,0.004837701,0.00008536583,0.007798799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007438114,"threshold_uncertainty_score":0.02488297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04660133977478886,"score_gpt":0.3800885671347362,"score_spread":0.3334872273599473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}