{"id":"W4379281020","doi":"10.1200/jco.2023.41.16_suppl.8002","title":"First results from the RedirecTT-1 study with teclistamab (tec) + talquetamab (tal) simultaneously targeting BCMA and GPRC5D in patients (pts) with relapsed/refractory multiple myeloma (RRMM).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; McGill University","funders":"Janssen Research and Development","keywords":"Medicine; Internal medicine; Neutropenia; Oncology; Multiple myeloma; Lenalidomide; Regimen; Alemtuzumab; Bortezomib; Chemotherapy; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0017496,0.001000452,0.001461508,0.0003046406,0.000294359,0.001030459,0.0004841086,0.001051455,0.003006811],"category_scores_gemma":[0.001255414,0.0004283528,0.001507625,0.0003817631,0.0004891097,0.0008599579,0.0004252247,0.002290067,0.0009007243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008125695,"about_ca_system_score_gemma":0.0007193294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004873886,"about_ca_topic_score_gemma":0.001747012,"domain_scores_codex":[0.9995279,0.000237404,0.00003488946,0.00006008831,0.00006265439,0.00007699791],"domain_scores_gemma":[0.9992768,0.0001624939,0.0001712188,0.00006111876,0.00004759589,0.0002807232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7732362,0.02732063,0.01913114,0.001487992,0.004307745,0.0005871422,0.0004889109,0.002697231,0.02910839,0.0003161105,0.009219917,0.1320987],"study_design_scores_gemma":[0.4398002,0.4963159,0.04327916,0.0001433937,0.003036949,0.001091444,0.0001251992,0.001327895,0.004704066,0.0003952185,0.009720578,0.00006000041],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844766,0.005945544,0.0006063093,0.0007614641,0.0001104831,0.001450737,0.002442977,0.00009584774,0.004110074],"genre_scores_gemma":[0.9857657,0.002682063,0.001160366,0.001469552,0.0002116077,0.001068901,0.004807574,0.00004179172,0.002792382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003006811,"threshold_uncertainty_score":0.01005882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05943540418970244,"score_gpt":0.3796287968766242,"score_spread":0.3201933926869217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}