{"id":"W4379281047","doi":"10.1200/jco.2023.41.16_suppl.8537","title":"Phase 1 trial of gavocabtagene autoleucel (gavo-cel, TC-210) in patients (pts) with treatment refractory mesothelioma and other mesothelin-expressing solid tumors.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Mesothelin; Medicine; Mesothelioma; Cancer research; Oncology; Ovarian cancer; Internal medicine; Cancer; Gastroenterology; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005467419,0.0007837199,0.0007223881,0.0002067027,0.0002495326,0.0005571584,0.0004446986,0.0007494518,0.003082042],"category_scores_gemma":[0.0002923782,0.0002759489,0.0005211626,0.0002058252,0.0005145496,0.0003901794,0.0002197653,0.001477501,0.000777752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006799868,"about_ca_system_score_gemma":0.0009342257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008663744,"about_ca_topic_score_gemma":0.002387388,"domain_scores_codex":[0.9998925,0.00004292104,0.000004270833,0.0000208591,0.0000107737,0.00002871484],"domain_scores_gemma":[0.999797,0.00003338574,0.00003940189,0.00001585421,0.000009608347,0.0001046475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5318642,0.06725105,0.02557455,0.001244527,0.0009449637,0.0009969196,0.0007915964,0.005512488,0.1934136,0.000928845,0.01164246,0.1598348],"study_design_scores_gemma":[0.3042345,0.6388807,0.02659629,0.00006625774,0.0004278279,0.001157938,0.0001617547,0.002401284,0.01511956,0.0004062086,0.01052066,0.00002702566],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995025,0.00104304,0.0003714888,0.0002434506,0.0000451245,0.001193573,0.0006042286,0.00007225468,0.001401916],"genre_scores_gemma":[0.9925914,0.0008420659,0.000818702,0.0004455401,0.00005878901,0.001250445,0.001437756,0.00002077261,0.002534538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003082042,"threshold_uncertainty_score":0.01031041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1679472589828233,"score_gpt":0.5078129524008199,"score_spread":0.3398656934179966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}