{"id":"W4379281207","doi":"10.1200/jco.2023.41.16_suppl.e18623","title":"Real world evidence for continuing HER2-directed therapy for metastatic breast cancer.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; BC Cancer Agency","funders":"","keywords":"Medicine; Pertuzumab; Trastuzumab; Metastatic breast cancer; Cohort; Breast cancer; Systemic therapy; Cancer; Internal medicine; Pharmacy; Oncology; Family medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004095278,0.0001815148,0.001786087,0.0002208119,0.0000578,0.00001182996,0.0002133802,0.0001435164,0.0001216068],"category_scores_gemma":[0.003521023,0.0001291975,0.0007329663,0.0004369106,0.000205953,0.0001995794,0.00002549741,0.0004985387,0.000005816557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002767539,"about_ca_system_score_gemma":0.001523755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006116442,"about_ca_topic_score_gemma":0.0002308122,"domain_scores_codex":[0.9966795,0.0002561764,0.002077711,0.000263276,0.0003088655,0.0004144729],"domain_scores_gemma":[0.984202,0.01224433,0.001852495,0.0001920713,0.00120092,0.0003081331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.04139834,0.0004548875,0.01730195,0.0001090099,0.0009493487,0.00009888643,0.0002147005,0.00008105501,0.001783941,0.00009751217,0.006573515,0.9309369],"study_design_scores_gemma":[0.04225139,0.01510269,0.6108886,0.00184275,0.001031978,0.0004625342,0.0004099845,0.001623253,0.0005496808,0.004113823,0.3213925,0.0003308458],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.907888,0.004352855,0.004171305,0.0756117,0.005161095,0.002277924,0.0001236437,0.0002160741,0.0001974152],"genre_scores_gemma":[0.9041307,0.01548109,0.06223017,0.005076802,0.00826382,0.0004154037,0.00001280416,0.000139913,0.004249311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.930606,"threshold_uncertainty_score":0.5268524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2959717089241489,"score_gpt":0.5694901139097674,"score_spread":0.2735184049856186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}