{"id":"W4379281451","doi":"10.1200/jco.2023.41.16_suppl.9017","title":"Intracranial and systemic efficacy of repotrectinib in advanced <i>ROS1</i> fusion-positive (<i>ROS1</i>+) non-small cell lung cancer (NSCLC) and central nervous system metastases (CNS mets) in the phase 1/2 TRIDENT-1.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System; University of Toronto","funders":"","keywords":"Medicine; ROS1; Internal medicine; Oncology; Lung cancer; Cohort; Cancer; Adenocarcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004782528,0.0005837359,0.0009470089,0.0002508924,0.0001322788,0.0005537888,0.0004889044,0.0003902633,0.002761391],"category_scores_gemma":[0.0004817489,0.0002100244,0.0007850979,0.0002768547,0.000453667,0.0006192789,0.0002356179,0.001967653,0.0005462726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007665919,"about_ca_system_score_gemma":0.0008170482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001305357,"about_ca_topic_score_gemma":0.003974836,"domain_scores_codex":[0.9998096,0.00006471885,0.00001024119,0.00003587357,0.00002497288,0.00005458987],"domain_scores_gemma":[0.9996978,0.00004121197,0.00008382351,0.00003198155,0.00001751699,0.0001277644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5412838,0.0368961,0.01104068,0.001369234,0.001629883,0.0004427353,0.000322351,0.005467452,0.1002351,0.0004242952,0.01218556,0.2887028],"study_design_scores_gemma":[0.1627373,0.7329854,0.06644535,0.0001175051,0.001627139,0.001205089,0.0002058519,0.005050106,0.02248328,0.0004631469,0.006607682,0.00007204799],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939552,0.002318372,0.0002564567,0.0001837858,0.00005038848,0.0002828222,0.0008717815,0.00009432977,0.00198696],"genre_scores_gemma":[0.9950653,0.001177853,0.0003071284,0.0001978336,0.00006832046,0.0002582955,0.001755708,0.00002431754,0.00114534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002761391,"threshold_uncertainty_score":0.009237766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03745217575927975,"score_gpt":0.4448131267924545,"score_spread":0.4073609510331747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}