{"id":"W4379281518","doi":"10.1200/jco.2023.41.16_suppl.8011","title":"Long-term follow-up from MajesTEC-1 of teclistamab, a B-cell maturation antigen (BCMA) x CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma (RRMM).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"Janssen Research and Development","keywords":"Medicine; Internal medicine; Clinical endpoint; Surrogate endpoint; Multiple myeloma; Cytokine release syndrome; Oncology; Gastroenterology; Surgery; Cancer; Clinical trial; Immunotherapy; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001443519,0.0002510316,0.001696288,0.0005499371,0.00005441183,0.00001754513,0.0002688024,0.0005066718,0.0001689839],"category_scores_gemma":[0.00233125,0.0001721991,0.0004210875,0.0005489982,0.0002543131,0.0002560078,0.0001008651,0.001141838,0.00009939013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002398494,"about_ca_system_score_gemma":0.001110022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000108484,"about_ca_topic_score_gemma":0.0003932946,"domain_scores_codex":[0.9951499,0.0005334358,0.002499415,0.0003750268,0.0009740793,0.0004681144],"domain_scores_gemma":[0.9940718,0.002507033,0.001840171,0.0004127157,0.0006882363,0.0004799981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03084126,0.004291613,0.9198414,0.00006843426,0.0003943139,0.001995217,0.0001256578,0.000004466889,0.00169667,0.00000192428,0.0008141277,0.0399249],"study_design_scores_gemma":[0.055182,0.01182904,0.9304193,0.0003570487,0.0001434382,0.00001634989,0.00008126938,0.00009735605,0.0004201741,0.00002811814,0.001290683,0.0001352876],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970443,0.0002087148,0.00004440957,0.00047868,0.001070742,0.0006509249,0.00005595996,0.00002376983,0.0004225326],"genre_scores_gemma":[0.9966487,0.0008346463,0.001337912,0.0001000283,0.0003761185,0.000007311486,0.0002614367,0.00004289657,0.000390914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03978961,"threshold_uncertainty_score":0.7022076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07838029115917072,"score_gpt":0.4153798505117658,"score_spread":0.3369995593525951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}