{"id":"W4379281518","doi":"10.1200/jco.2023.41.16_suppl.8011","title":"Long-term follow-up from MajesTEC-1 of teclistamab, a B-cell maturation antigen (BCMA) x CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma (RRMM).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"Janssen Research and Development","keywords":"Medicine; Internal medicine; Clinical endpoint; Surrogate endpoint; Multiple myeloma; Cytokine release syndrome; Oncology; Gastroenterology; Surgery; Cancer; Clinical trial; Immunotherapy; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001996778,0.0003367426,0.000903418,0.0004279991,0.0005719635,0.001136475,0.0005266791,0.0007475477,0.001503801],"category_scores_gemma":[0.002031692,0.0002963337,0.001265953,0.0006134231,0.000242698,0.0009274777,0.0007366613,0.001578033,0.0005196007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000994414,"about_ca_system_score_gemma":0.0005838906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002442545,"about_ca_topic_score_gemma":0.003837216,"domain_scores_codex":[0.9993513,0.0001509276,0.00007574553,0.0001675038,0.00009612242,0.0001583087],"domain_scores_gemma":[0.9982806,0.000261227,0.0006048355,0.0001808344,0.0002135573,0.00045894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.08522987,0.002627876,0.7659516,0.0005761985,0.00332063,0.002026208,0.0007791837,0.001827882,0.00806572,0.000168858,0.008209526,0.1212164],"study_design_scores_gemma":[0.003804978,0.02525612,0.9520686,0.0002383477,0.003181525,0.001917227,0.0002469772,0.001237213,0.001330794,0.0001941275,0.01046214,0.00006197803],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906151,0.004734443,0.0003318545,0.0003184138,0.00005384206,0.0001110927,0.002359891,0.00002845181,0.001446828],"genre_scores_gemma":[0.9903845,0.001023211,0.0002615521,0.0006101019,0.00009339037,0.0001179849,0.006540767,0.000008598548,0.0009600269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002442545,"threshold_uncertainty_score":0.01056015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07838029115917072,"score_gpt":0.4153798505117658,"score_spread":0.3369995593525951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}