{"id":"W4379281712","doi":"10.1200/jco.2023.41.16_suppl.5525","title":"Neoplastic and blood-based biomarkers of response in patients with advanced endometrial cancer: Results from NRG GY012.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Institutes of Health","keywords":"Medicine; Olaparib; PARP inhibitor; Oncology; Biomarker; Ovarian cancer; Internal medicine; Endometrial cancer; PALB2; Somatic cell; Circulating tumor cell; Multiplex; Loss of heterozygosity; Cancer; Germline mutation; Bioinformatics; Gene; Metastasis; Poly ADP ribose polymerase; Biology; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001972127,0.0004750582,0.0007533912,0.0002732724,0.0001339041,0.0003554825,0.000351615,0.0003881732,0.0008887622],"category_scores_gemma":[0.001393733,0.0001785408,0.0008168934,0.0004825888,0.0002718102,0.0001565631,0.0002288571,0.0005233692,0.0002551095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007989168,"about_ca_system_score_gemma":0.0007177257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002798517,"about_ca_topic_score_gemma":0.003961809,"domain_scores_codex":[0.9995309,0.0002402719,0.00003663858,0.00007782512,0.00007532754,0.00003907162],"domain_scores_gemma":[0.9992597,0.0002086025,0.0001720564,0.00008397901,0.00006305966,0.0002127494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3977035,0.003483704,0.3810299,0.0009572007,0.002889957,0.0003682629,0.0003501204,0.00214726,0.02239527,0.0001638314,0.004165316,0.1843456],"study_design_scores_gemma":[0.04166628,0.07824389,0.8664405,0.0001178178,0.002582962,0.000544559,0.0001140579,0.001083663,0.002690095,0.0001153184,0.006366161,0.00003473579],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914484,0.005952423,0.0001562709,0.0002085338,0.00002440759,0.0001553447,0.001343488,0.00001832458,0.0006928761],"genre_scores_gemma":[0.9947128,0.0009118386,0.0003377068,0.0003452977,0.00003731137,0.00008991468,0.003174017,0.000004840383,0.0003861836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002798517,"threshold_uncertainty_score":0.01042974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07966472871351292,"score_gpt":0.4464484640246096,"score_spread":0.3667837353110966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}