{"id":"W4379281889","doi":"10.1200/jco.2023.41.16_suppl.tps7582","title":"BRUIN CLL-321: A phase 3 open-label, randomized study of pirtobrutinib versus investigator’s choice of idelalisib plus rituximab or bendamustine plus rituximab in BTK inhibitor pretreated chronic lymphocytic leukemia/small lymphocytic lymphoma.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Bruton's tyrosine kinase; Ibrutinib; Bendamustine; Chronic lymphocytic leukemia; Idelalisib; Rituximab; Medicine; Venetoclax; Internal medicine; Pharmacology; Oncology; Immunology; Leukemia; Lymphoma; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002188137,0.001753954,0.002395402,0.0005070009,0.0004815517,0.0013492,0.001108695,0.002307042,0.007044124],"category_scores_gemma":[0.001432878,0.0007810542,0.00200852,0.0003756477,0.001249971,0.00169374,0.0004833542,0.004375518,0.001537976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001058777,"about_ca_system_score_gemma":0.001285166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008047282,"about_ca_topic_score_gemma":0.002199217,"domain_scores_codex":[0.9993576,0.0003370387,0.0000283526,0.0001087387,0.00004497469,0.0001232432],"domain_scores_gemma":[0.9992033,0.0001894412,0.0001647855,0.00005665621,0.00004621954,0.0003396495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9590259,0.01640162,0.0005964487,0.0003665579,0.0006088775,0.00004904469,0.00006207194,0.0004200417,0.004248919,0.0001415022,0.001081794,0.01699722],"study_design_scores_gemma":[0.8904693,0.1058625,0.001403585,0.00002475157,0.0002651371,0.0000475603,0.00002568188,0.0004959491,0.0003096187,0.0001825191,0.0008947591,0.00001859599],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983163,0.004714543,0.0008535702,0.001159062,0.0006661551,0.004865092,0.001214,0.0002073781,0.003157162],"genre_scores_gemma":[0.9837202,0.002512054,0.001815191,0.001939489,0.0005820424,0.005055173,0.001323167,0.00004222989,0.003010564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007044124,"threshold_uncertainty_score":0.02356499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3351016108582622,"score_gpt":0.5299669314419019,"score_spread":0.1948653205836396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}