{"id":"W4379282075","doi":"10.1200/jco.2023.41.16_suppl.5027","title":"AI-enabled analysis of H&E-stained prostate cancer tissue images: Assessing risk for metastasis prior to apalutamide (APA) treatment of patients with non-metastatic castration-resistant prostate cancer (nmCRPC).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Janssen Research and Development","keywords":"Medicine; Prostate cancer; Metastasis; Prostatectomy; Oncology; Internal medicine; Androgen deprivation therapy; Cancer; Prostate; Placebo; Disease; Urology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007614724,0.0001884466,0.0002402401,0.0004200485,0.000147096,0.0002828427,0.0003069124,0.0001971155,0.001273906],"category_scores_gemma":[0.001120467,0.0001376784,0.0001886465,0.0002851276,0.0002583427,0.0001902092,0.0002457776,0.0002432222,0.0002038444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003012418,"about_ca_system_score_gemma":0.0002712141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005991465,"about_ca_topic_score_gemma":0.001095983,"domain_scores_codex":[0.9996817,0.0001164386,0.00002482384,0.00007523529,0.00008370219,0.00001813043],"domain_scores_gemma":[0.9993532,0.0001710449,0.0002594687,0.00005417545,0.00008367604,0.00007847214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04633963,0.001690151,0.7830941,0.0004812262,0.0003108262,0.0003296458,0.0001915877,0.001032551,0.08575079,0.0001104302,0.0009957612,0.07967328],"study_design_scores_gemma":[0.0007709679,0.01441873,0.9586049,0.00001782926,0.0001722835,0.001012173,0.00008385886,0.00207831,0.02134875,0.00006890888,0.001407401,0.00001585651],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978366,0.0004941213,0.0005746803,0.0000202654,0.000007047163,0.0001785794,0.0005053576,0.00001518981,0.0003681695],"genre_scores_gemma":[0.9967794,0.0002051781,0.001861336,0.00002690012,0.00001068604,0.0001418753,0.0007262845,0.000004010011,0.0002442655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001273906,"threshold_uncertainty_score":0.004261613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1143294209150498,"score_gpt":0.5153988634597378,"score_spread":0.401069442544688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}