{"id":"W4379282095","doi":"10.1200/jco.2023.41.16_suppl.e15094","title":"A first-in-human, open-label, phase I trial of daily oral PCLX-001, an NMT inhibitor, in patients with relapsed/refractory B-cell lymphomas and advanced solid tumors.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; Spinal Cord Injury BC; University Health Network; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Neutropenia; Pharmacology; Cancer; Lymphoma; Pharmacokinetics; Refractory (planetary science); Toxicity; Internal medicine; Cancer research; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001083426,0.001761419,0.001576677,0.0004423871,0.0005562718,0.001262272,0.001180771,0.001576174,0.004305389],"category_scores_gemma":[0.0006252385,0.0007214661,0.0008577601,0.0003466091,0.001262736,0.001597611,0.0004292398,0.003462206,0.001187442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00105838,"about_ca_system_score_gemma":0.001455209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008297378,"about_ca_topic_score_gemma":0.00232218,"domain_scores_codex":[0.9996908,0.0001053467,0.000014682,0.00007394194,0.00002779198,0.00008756196],"domain_scores_gemma":[0.9993844,0.00007810546,0.0000921716,0.00005627077,0.00003530023,0.0003537564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5702263,0.1484048,0.008403858,0.001217888,0.001100831,0.000806773,0.0006318439,0.004388175,0.1195907,0.0008246686,0.009904969,0.1344991],"study_design_scores_gemma":[0.444423,0.5266362,0.01026604,0.00003523818,0.0003347013,0.0006327403,0.0001342882,0.00214944,0.008849877,0.000460012,0.006036076,0.00004227735],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878749,0.001774487,0.0009989358,0.0006370423,0.0001410751,0.004166139,0.001646965,0.0002127267,0.00254774],"genre_scores_gemma":[0.9840659,0.001340006,0.002471133,0.001267863,0.0001397695,0.003711299,0.00287867,0.00007030601,0.004055054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004305389,"threshold_uncertainty_score":0.01440299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08867594655244497,"score_gpt":0.4542369393706819,"score_spread":0.3655609928182369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}