{"id":"W4379282163","doi":"10.1200/jco.2023.41.16_suppl.11509","title":"Molecular residual disease (MRD) detection using bespoke circulating tumor DNA (ctDNA) assays in localized soft tissue sarcoma (STS).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Princess Margaret Cancer Centre; University Health Network","funders":"Natera; Conquer Cancer Foundation","keywords":"Medicine; Circulating tumor DNA; Internal medicine; Oncology; Adjuvant; Minimal residual disease; Population; Cancer; Clinical endpoint; Sarcoma; Gastroenterology; Pathology; Clinical trial; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00096801,0.0002754511,0.0003813655,0.0005836975,0.0001226619,0.0005608094,0.0002937406,0.0005305202,0.0009818311],"category_scores_gemma":[0.001180696,0.000183591,0.0002426693,0.0003627719,0.0002938078,0.0002855038,0.0002273464,0.0003635941,0.0005367402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002772535,"about_ca_system_score_gemma":0.0001708632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003942184,"about_ca_topic_score_gemma":0.0009545425,"domain_scores_codex":[0.9994252,0.000151868,0.00006056468,0.0001977528,0.0001297307,0.00003497158],"domain_scores_gemma":[0.9993055,0.0002185112,0.0002476512,0.00004809277,0.00009269338,0.00008755185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006933546,0.0005800309,0.7259638,0.0006863346,0.0002520924,0.0007263065,0.0002337493,0.001428936,0.1620435,0.0001178186,0.001244101,0.09978975],"study_design_scores_gemma":[0.000284633,0.01356916,0.9018843,0.00008511874,0.0004877427,0.003796487,0.0001971967,0.007525302,0.06618763,0.0001865953,0.005752053,0.00004389157],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900283,0.004993259,0.002615707,0.00009545491,0.00004432099,0.0001211888,0.000839845,0.0000643018,0.001197503],"genre_scores_gemma":[0.9956225,0.0007071309,0.002111503,0.00008222634,0.00001746957,0.00008134126,0.0007215903,0.000006707519,0.0006495183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009818311,"threshold_uncertainty_score":0.005119383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06661750532639654,"score_gpt":0.4166488437109175,"score_spread":0.3500313383845209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}