{"id":"W4379282239","doi":"10.1200/jco.2023.41.16_suppl.tps5116","title":"PSMAddition: A phase 3 trial to compare treatment with <sup>177</sup>Lu-PSMA-617 plus standard of care (SoC) and SoC alone in patients with metastatic hormone-sensitive prostate cancer.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Prostate cancer; Androgen deprivation therapy; Clinical endpoint; Oncology; Internal medicine; Enzalutamide; Urology; Cancer; Randomized controlled trial; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007783045,0.0002374995,0.002321156,0.0003009384,0.00006507449,0.00001346172,0.00007490352,0.00009419854,0.00003526829],"category_scores_gemma":[0.0002567917,0.0001332351,0.000175457,0.0004683158,0.0003533922,0.0001140001,0.0000432968,0.0004647116,0.000003446078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009544494,"about_ca_system_score_gemma":0.003441121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001350157,"about_ca_topic_score_gemma":0.0005984125,"domain_scores_codex":[0.9968361,0.0003830871,0.00137925,0.0003065139,0.000713347,0.0003816519],"domain_scores_gemma":[0.996572,0.0008998337,0.0008028002,0.0001657599,0.001055156,0.0005044366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8656883,0.002651412,0.03461018,0.0001174043,0.001521483,0.002521043,0.005728784,0.0003635061,0.00001011846,0.000003817651,0.001651684,0.08513227],"study_design_scores_gemma":[0.5805897,0.336958,0.06970036,0.0006150925,0.001152464,0.00004587583,0.007055003,0.0001362134,0.0001937425,0.00002593971,0.003340816,0.0001868045],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932216,0.0006644276,0.00001175364,0.003322453,0.0001175599,0.001971992,0.0005756994,0.00001142736,0.000103038],"genre_scores_gemma":[0.9965178,0.001809637,0.0008432284,0.0001703297,0.0002530441,0.00009795733,0.000140586,0.00002805354,0.0001394027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3343066,"threshold_uncertainty_score":0.6104402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1116587552999057,"score_gpt":0.4791463726981037,"score_spread":0.367487617398198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}