{"id":"W4379282452","doi":"10.1200/jco.2023.41.16_suppl.tps10067","title":"LOGGIC/FIREFLY-2: A phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating <i>RAF</i> alteration.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Regimen; Tolerability; Internal medicine; Chemotherapy regimen; Lomustine; Glioma; Chemotherapy; Oncology; Interim analysis; Progression-free survival; Randomized controlled trial; Hazard ratio; Bedaquiline; Adverse effect; Surgery; Vincristine; Pathology; Cancer research; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001429625,0.002070118,0.001905596,0.0004580209,0.0004092652,0.001227116,0.001129172,0.0013541,0.006474903],"category_scores_gemma":[0.001091725,0.0006433692,0.001608611,0.0003741629,0.001004654,0.001272369,0.0004248174,0.00389277,0.0009690865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001377926,"about_ca_system_score_gemma":0.001972067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001730795,"about_ca_topic_score_gemma":0.006123797,"domain_scores_codex":[0.9996566,0.0001576646,0.00001355888,0.00005593783,0.00002755988,0.00008876098],"domain_scores_gemma":[0.9992704,0.0001197472,0.0001582738,0.00004031622,0.00003387392,0.0003774563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9498296,0.01722486,0.001450841,0.0005381278,0.0006740707,0.0001113689,0.0001170565,0.0006981207,0.004340132,0.0002552702,0.003540929,0.02121955],"study_design_scores_gemma":[0.8789536,0.11547,0.002355618,0.00003339429,0.0002486582,0.0001189351,0.00004593173,0.0007952001,0.0005209907,0.0002266837,0.001208982,0.00002203219],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987384,0.002630925,0.0004112005,0.0011653,0.0004440653,0.003484583,0.001975636,0.0002191087,0.002285182],"genre_scores_gemma":[0.976689,0.003041914,0.002043389,0.002280168,0.0004797181,0.006562427,0.003589549,0.00006767081,0.005246273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006474903,"threshold_uncertainty_score":0.02166075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04503749390740588,"score_gpt":0.4092387769605215,"score_spread":0.3642012830531156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}