{"id":"W4379282852","doi":"10.1200/jco.2023.41.16_suppl.tps3153","title":"TROPION-PanTumor03: Phase 2, multicenter study of datopotamab deruxtecan (Dato-DXd) as monotherapy and in combination with anticancer agents in patients (pts) with advanced/metastatic solid tumors.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Nivolumab; Prostate cancer; Internal medicine; Oncology; Cancer; Combination therapy; Bevacizumab; Cancer research; Immunotherapy; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001958447,0.0001750318,0.001551975,0.0005373468,0.00002602581,0.00001028272,0.0001801602,0.00009082345,0.00006634484],"category_scores_gemma":[0.001427926,0.000117258,0.00006514731,0.0006421987,0.0002182077,0.0001872908,0.0000580893,0.0008844517,0.000005402238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002670426,"about_ca_system_score_gemma":0.001217774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001171046,"about_ca_topic_score_gemma":0.0006489973,"domain_scores_codex":[0.995708,0.0006823279,0.002113444,0.0003083356,0.0008338754,0.0003539823],"domain_scores_gemma":[0.9967336,0.001126731,0.001162629,0.0002370603,0.0004642862,0.0002756927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03205436,0.01851021,0.8591753,0.0001089778,0.0002076552,0.001805673,0.000899397,0.0001339056,0.00005288867,0.000003885254,0.000106354,0.08694141],"study_design_scores_gemma":[0.1173945,0.08059835,0.7981028,0.000639252,0.00009384136,0.00003664898,0.001373091,0.001158568,0.00009251937,0.00007230382,0.0003344735,0.0001036692],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997433,0.00005811086,0.00003169437,0.001095742,0.0001624093,0.001152115,0.000005749707,0.000007034733,0.00005413372],"genre_scores_gemma":[0.9981279,0.0006650956,0.0006793529,0.0003764374,0.0000513655,0.00003009764,0.000005654943,0.00003373355,0.00003039052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08683774,"threshold_uncertainty_score":0.4781641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.139887455660775,"score_gpt":0.5423854401283179,"score_spread":0.4024979844675429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}