{"id":"W4379283180","doi":"10.1200/jco.2023.41.16_suppl.2580","title":"The initial report of phase I trial of VG2025, a non-attenuated HSV-1 oncolytic virus expressing IL-12 and IL-15/RA payloads, in patients with advanced solid tumors.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"","keywords":"Medicine; Oncolytic virus; Pharmacokinetics; Internal medicine; Gastroenterology; Colorectal cancer; Pharmacodynamics; Carcinoembryonic antigen; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008195798,0.0008000615,0.0007780052,0.0001372621,0.0002357671,0.0006402245,0.0003848805,0.0009694435,0.002492129],"category_scores_gemma":[0.000524217,0.0002415907,0.0005550814,0.0001279128,0.000421375,0.0004359696,0.0002098241,0.001457577,0.0005786317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005227766,"about_ca_system_score_gemma":0.0006682834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006721732,"about_ca_topic_score_gemma":0.001911731,"domain_scores_codex":[0.999826,0.00006328335,0.00001128521,0.00003205653,0.0000168775,0.00005045182],"domain_scores_gemma":[0.9996732,0.00009053612,0.00004302395,0.0000259778,0.00002359943,0.000143597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3793898,0.06498286,0.02409381,0.001609464,0.001593547,0.002846176,0.0008431571,0.00547488,0.2480609,0.001289038,0.01754543,0.252271],"study_design_scores_gemma":[0.2017015,0.7189343,0.02825438,0.000100192,0.0005356391,0.0016833,0.0001256133,0.002818019,0.03097912,0.000630439,0.01419944,0.00003802801],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817664,0.002366605,0.002929891,0.0008584954,0.0002469839,0.003784748,0.002956336,0.0002072952,0.004883295],"genre_scores_gemma":[0.9870635,0.0008678274,0.001763369,0.00116994,0.0001163835,0.001543079,0.00359367,0.00003253649,0.003849625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002492129,"threshold_uncertainty_score":0.008337021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07195290089014271,"score_gpt":0.4714039475880513,"score_spread":0.3994510466979086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}