{"id":"W4379283222","doi":"10.1200/jco.2023.41.16_suppl.tps2670","title":"A phase I/II dose escalation and expansion trial to evaluate safety and preliminary efficacy of BNT141 in patients with claudin-18.2-positive solid tumors.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Gemcitabine; Tolerability; Radioimmunotherapy; Antibody; Internal medicine; Chemotherapy; Adverse effect; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001724483,0.0001182244,0.0009057072,0.0002085648,0.000105906,0.000007427585,0.00007951281,0.000139158,0.00001262801],"category_scores_gemma":[0.005595165,0.00007861661,0.00008151124,0.0003468412,0.0002339939,0.0001550937,0.0001468164,0.0004000453,0.000001704398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003427423,"about_ca_system_score_gemma":0.0002132203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002845951,"about_ca_topic_score_gemma":0.000004230381,"domain_scores_codex":[0.9970979,0.0005923482,0.001541168,0.0002560266,0.0003466738,0.0001658763],"domain_scores_gemma":[0.9956201,0.002897713,0.001004887,0.00009279154,0.0002073157,0.0001772153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6670351,0.002772339,0.01444295,0.00001618712,0.00006405955,0.0001058262,0.001881371,0.0001796348,0.001678299,0.00004618182,0.0006864572,0.3110916],"study_design_scores_gemma":[0.1312431,0.1036637,0.7633584,0.00008794348,0.0000954971,0.00001675496,0.00009707892,0.0002135002,0.0004432183,0.0001629587,0.0005260269,0.00009185541],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974627,0.00002075081,0.00006966541,0.001098232,0.0007011388,0.0004513263,0.000009931362,0.000007066818,0.0001792056],"genre_scores_gemma":[0.998997,0.0001222724,0.0001584551,0.000479455,0.0001998504,0.00000358365,0.000001262646,0.000008174084,0.00002992551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7489154,"threshold_uncertainty_score":0.6698339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1110016579375653,"score_gpt":0.4566002010796958,"score_spread":0.3455985431421305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}