{"id":"W4379283397","doi":"10.1200/jco.2023.41.16_suppl.5097","title":"Comparative real-world (RW) evidence on darolutamide (Daro), enzalutamide (Enza), and apalutamide (Apa) for patients (Pts) with nonmetastatic castration-resistant prostate cancer (nmCRPC) in the United States: DEAR.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bayer (Canada)","funders":"Bayer","keywords":"Medicine; Enzalutamide; Prostate cancer; Internal medicine; Adverse effect; Proportional hazards model; Cohort; Oncology; Cancer; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01427661,0.0003417106,0.001028427,0.001681777,0.0002642076,0.001630357,0.0008309935,0.0008452607,0.005923191],"category_scores_gemma":[0.03815231,0.0003088429,0.002790115,0.002820912,0.0006188213,0.001039311,0.000698672,0.0007951761,0.0004408758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001163612,"about_ca_system_score_gemma":0.001641234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001656395,"about_ca_topic_score_gemma":0.004960068,"domain_scores_codex":[0.9863688,0.008426104,0.002725404,0.000740279,0.001445893,0.0002935511],"domain_scores_gemma":[0.9393231,0.02765692,0.02846533,0.001314195,0.00228529,0.0009552049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09650389,0.001344267,0.3667133,0.1117142,0.06404585,0.0004200823,0.0005581024,0.001730703,0.002211665,0.002427901,0.01335817,0.3389718],"study_design_scores_gemma":[0.03815123,0.03774219,0.6449929,0.06550412,0.1182608,0.003233256,0.002106046,0.001977952,0.002396001,0.00146233,0.08397949,0.0001936019],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4165984,0.5431443,0.001326428,0.005021174,0.0005407318,0.001240691,0.0232436,0.00004975299,0.008834925],"genre_scores_gemma":[0.9095608,0.07858387,0.002122052,0.002890727,0.000497226,0.0004634105,0.005350023,0.00002346886,0.0005084058],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01427661,"threshold_uncertainty_score":0.07550281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2668486127059642,"score_gpt":0.5243409152184116,"score_spread":0.2574923025124474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}