{"id":"W4379283399","doi":"10.1200/jco.2023.41.16_suppl.tps2671","title":"Trial START-001: A phase 1/2 study of STAR0602, a first-in-class, selective T cell receptor (TCR)-targeting, bifunctional antibody-fusion molecule, as monotherapy in patients with antigen-rich tumors post checkpoint inhibitor (CPI) treatment.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Tolerability; T-cell receptor; CD8; Antigen; Immunology; Cytokine release syndrome; Cancer research; T cell; Pharmacology; Oncology; Internal medicine; Immune system; Chimeric antigen receptor; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001079759,0.001716417,0.001150263,0.0003694679,0.0003379147,0.001189132,0.0007717027,0.001645148,0.005112934],"category_scores_gemma":[0.0005470339,0.0004249992,0.0008796037,0.0003169239,0.0007556255,0.00094962,0.0003320422,0.003029815,0.001436182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007280161,"about_ca_system_score_gemma":0.001375567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005856287,"about_ca_topic_score_gemma":0.001619151,"domain_scores_codex":[0.9997688,0.00009745045,0.000008222911,0.00004471455,0.00002212397,0.00005868481],"domain_scores_gemma":[0.9996718,0.00005120457,0.00005818895,0.00002100087,0.00002834013,0.0001694355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.612881,0.07206125,0.005974957,0.002033115,0.001397154,0.0009010858,0.0004994952,0.005228182,0.122377,0.002301855,0.02737025,0.1469746],"study_design_scores_gemma":[0.4905891,0.4779141,0.00481412,0.0000861256,0.0004065487,0.0009373101,0.0001027347,0.002338481,0.01196982,0.0006976277,0.01010055,0.00004354708],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727338,0.005534462,0.002318671,0.001755827,0.0003141951,0.004943641,0.005431561,0.0005130306,0.006454781],"genre_scores_gemma":[0.9557824,0.004853173,0.004516686,0.003127673,0.000252337,0.006291854,0.01241311,0.0001576498,0.01260492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005112934,"threshold_uncertainty_score":0.01710451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05782763094872354,"score_gpt":0.4341434159589589,"score_spread":0.3763157850102354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}