{"id":"W4379283867","doi":"10.1200/jco.2023.41.16_suppl.tps3161","title":"FRONTIER: FAPi radioligand open-label, phase 1 study to evaluate safety, tolerability and dosimetry of [Lu-177]-PNT6555—A dose escalation study for treatment of patients with select solid tumors.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal; Jewish General Hospital","funders":"","keywords":"Medicine; Tolerability; Fibroblast activation protein, alpha; Pancreatic cancer; Cancer; Pharmacokinetics; Response Evaluation Criteria in Solid Tumors; DOTA; Tumor microenvironment; Cancer research; Phases of clinical research; Oncology; Clinical trial; Internal medicine; Adverse effect; In vivo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002208106,0.002591727,0.002239054,0.0007418929,0.0006733118,0.001379372,0.001642517,0.001823399,0.004677947],"category_scores_gemma":[0.0009925701,0.001016031,0.001220841,0.0006862113,0.001654883,0.00144767,0.000461363,0.003796323,0.001638466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002896825,"about_ca_system_score_gemma":0.002661972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00195407,"about_ca_topic_score_gemma":0.003745289,"domain_scores_codex":[0.9992477,0.0002934796,0.00002574256,0.0001914332,0.0001005864,0.0001412314],"domain_scores_gemma":[0.9989692,0.0001103021,0.0003313743,0.0000936658,0.00006569267,0.0004297477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5262291,0.1428505,0.006913572,0.001230887,0.001093358,0.0005820456,0.0007014118,0.006271142,0.2217584,0.0009132697,0.008714697,0.08274177],"study_design_scores_gemma":[0.222658,0.7419472,0.01036603,0.00004360504,0.0005159159,0.0008026971,0.0001183507,0.002430178,0.01507231,0.0003067742,0.005679133,0.00006000041],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986106,0.001546702,0.001969442,0.000434997,0.0001192936,0.004753313,0.002769094,0.0002488265,0.002052194],"genre_scores_gemma":[0.9809841,0.001285069,0.004454399,0.0009548809,0.0001442744,0.004705421,0.003900141,0.0001008099,0.003471019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004677947,"threshold_uncertainty_score":0.02101809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1519913875656884,"score_gpt":0.5253792704416357,"score_spread":0.3733878828759473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}