{"id":"W4379284089","doi":"10.1200/jco.2023.41.16_suppl.tps616","title":"lidERA Breast Cancer (BC): Phase III adjuvant study of giredestrant vs. physician’s choice of endocrine therapy (PCET) in patients (pts) with estrogen receptor-positive, HER2-negative early BC (ER+, HER2– eBC).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Letrozole; Tamoxifen; Internal medicine; Anastrozole; Oncology; Exemestane; Fulvestrant; Breast cancer; Tolerability; Estrogen receptor; Hazard ratio; Adverse effect; Cancer; Gynecology; Confidence interval","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001846092,0.001777355,0.001622334,0.0006989454,0.0003493365,0.0007824025,0.001171245,0.001530333,0.009316528],"category_scores_gemma":[0.001439689,0.000682103,0.001580493,0.0005171593,0.0009682605,0.0008585975,0.0004570804,0.003712978,0.001572458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008941431,"about_ca_system_score_gemma":0.001479367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001845309,"about_ca_topic_score_gemma":0.005363617,"domain_scores_codex":[0.9994968,0.0002914962,0.00001841353,0.00006836246,0.00004771213,0.00007719358],"domain_scores_gemma":[0.999317,0.000182384,0.000133893,0.00005310476,0.00003633257,0.0002771856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9037759,0.04630851,0.002029221,0.000778501,0.0008446717,0.00004750615,0.0001050336,0.001140938,0.005448628,0.0002071055,0.00245023,0.03686374],"study_design_scores_gemma":[0.7384297,0.2535988,0.003990795,0.00004106418,0.0004795373,0.00007510946,0.00004518297,0.0007056787,0.000656338,0.0001566144,0.001804216,0.00001690978],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795967,0.004273056,0.0005962087,0.0008675571,0.0003985079,0.006054151,0.002573231,0.0002405574,0.005399955],"genre_scores_gemma":[0.9721689,0.004177264,0.00301204,0.001897293,0.0004230615,0.006610177,0.003882894,0.0000566205,0.007771829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009316528,"threshold_uncertainty_score":0.03116691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05948224414837465,"score_gpt":0.4391421162090012,"score_spread":0.3796598720606266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}