{"id":"W4379284101","doi":"10.1056/nejmoa2304194","title":"Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":719,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Servier","keywords":"IDH2; IDH1; Glioma; Mutant; Biology; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009411288,0.0002098462,0.000781998,0.0008982093,0.00003586125,0.00001099969,0.0001288117,0.0000868163,0.0005773836],"category_scores_gemma":[0.0008670692,0.0001127973,0.0001136941,0.001118529,0.000072377,0.00008597318,0.00002635538,0.000350172,0.00004898291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150953,"about_ca_system_score_gemma":0.0002723835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001932938,"about_ca_topic_score_gemma":0.0001972051,"domain_scores_codex":[0.9978617,0.00007455475,0.0008023286,0.0001763226,0.0007378272,0.0003472499],"domain_scores_gemma":[0.9984441,0.0004418767,0.0002715866,0.0002172193,0.0001322989,0.0004929654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.00712523,0.001445837,0.217252,0.0002861045,0.0007992173,0.1916451,0.005085669,0.000172376,0.2164621,0.000315522,0.1196318,0.239779],"study_design_scores_gemma":[0.4401343,0.01272791,0.3533004,0.008357476,0.001221477,0.0392837,0.002160375,0.0004165192,0.04661947,0.002872063,0.09237737,0.0005289302],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637672,0.001568782,0.00001625709,0.03325064,0.0007617636,0.0002153052,0.000002354588,0.00003093839,0.000386727],"genre_scores_gemma":[0.9946676,0.001320143,0.0001647751,0.0004998069,0.00302615,0.000004372079,0.000008713441,0.00002725464,0.0002812007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4330091,"threshold_uncertainty_score":0.6321945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03557664761213593,"score_gpt":0.3223266738010366,"score_spread":0.2867500261889007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}