{"id":"W4379284101","doi":"10.1056/nejmoa2304194","title":"Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":719,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Servier","keywords":"IDH2; IDH1; Glioma; Mutant; Biology; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006309827,0.0003129629,0.0009076651,0.0002197586,0.0001022453,0.0002816925,0.0002293446,0.0002737934,0.001988966],"category_scores_gemma":[0.0005985264,0.0001041951,0.000391547,0.0002256036,0.0002994544,0.0002239645,0.0001305796,0.0006215228,0.0001868431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004930539,"about_ca_system_score_gemma":0.0004793795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003574918,"about_ca_topic_score_gemma":0.0009550438,"domain_scores_codex":[0.9998236,0.00008942995,0.00002044439,0.00002290941,0.00002177413,0.00002175047],"domain_scores_gemma":[0.9997401,0.0001045698,0.00006727752,0.00001369459,0.00001378393,0.00006054657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5681407,0.005567566,0.01077871,0.00334742,0.001369241,0.0005094871,0.0001968263,0.003196855,0.05144065,0.0007520969,0.002647456,0.3520529],"study_design_scores_gemma":[0.4040425,0.4992534,0.04875305,0.0003666644,0.002151121,0.001753804,0.000149667,0.004110139,0.02506824,0.001508503,0.01279251,0.00005034441],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865779,0.0115021,0.0002980372,0.0002246934,0.00007830087,0.0001891688,0.0001414178,0.00002507859,0.0009632335],"genre_scores_gemma":[0.9952252,0.003698417,0.0002877695,0.0001181581,0.00007080128,0.0001086476,0.0001849614,0.000003477571,0.0003025279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001988966,"threshold_uncertainty_score":0.006653786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03557664761213593,"score_gpt":0.3223266738010366,"score_spread":0.2867500261889007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}