{"id":"W4379284138","doi":"10.1056/nejmoa2303269","title":"Preoperative Treatment of Locally Advanced Rectal Cancer","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":448,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba","funders":"National Cancer Institute; National Institutes of Health; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung; NRG Oncology; ECOG-ACRIN Cancer Research Group; American College of Radiology Imaging Network; Alliance for Clinical Trials in Oncology Foundation","keywords":"FOLFOX; Medicine; Hazard ratio; Oxaliplatin; Colorectal cancer; Chemoradiotherapy; Clinical endpoint; Surgery; Internal medicine; Oncology; Confidence interval; Radiation therapy; Randomized controlled trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005073371,0.0002002398,0.0004958017,0.0001431174,0.0002580074,0.0001948055,0.0001764594,0.0002104424,0.003053655],"category_scores_gemma":[0.00156648,0.0001129532,0.0003231813,0.0001738943,0.0002592541,0.0001548629,0.0001926947,0.0004127717,0.0002530208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003142126,"about_ca_system_score_gemma":0.0006696159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003349651,"about_ca_topic_score_gemma":0.000939485,"domain_scores_codex":[0.9996969,0.0001569649,0.00003632815,0.0000302335,0.00004064899,0.00003898814],"domain_scores_gemma":[0.9991856,0.0003192969,0.0002442235,0.0000442584,0.00003339392,0.0001732467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2518482,0.008130593,0.3156198,0.00598174,0.0008670324,0.0009585224,0.0004823379,0.002794602,0.02891814,0.0005231743,0.004438982,0.3794369],"study_design_scores_gemma":[0.02508481,0.3247454,0.6161442,0.0006843082,0.001304736,0.004282665,0.0004044263,0.001706263,0.01069462,0.0005371166,0.01433601,0.00007540111],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918978,0.005906392,0.0003364968,0.0003595989,0.00008057828,0.0001769727,0.0001427409,0.00002150453,0.00107791],"genre_scores_gemma":[0.997484,0.001319969,0.0004348542,0.0001634072,0.00006634682,0.0001558432,0.0001461347,0.00000200214,0.0002275103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003053655,"threshold_uncertainty_score":0.01021552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03744182590264006,"score_gpt":0.351940593823846,"score_spread":0.3144987679212059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}