{"id":"W4379284572","doi":"10.1200/jco.2023.41.16_suppl.e12595","title":"Informative tools to optimize neoadjuvant therapy in ER positive, HER2 negative breast cancers.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"BC Cancer Foundation","keywords":"Medicine; Breast cancer; Nat; Internal medicine; Oncology; Neoadjuvant therapy; Biopsy; Cancer; Pathological; Chemotherapy; Gynecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001708262,0.0007041989,0.0004968143,0.002559578,0.0002629263,0.001097763,0.0003855197,0.000386149,0.006372679],"category_scores_gemma":[0.005750637,0.0002058223,0.0002822767,0.001393036,0.0001799533,0.0005411351,0.000407605,0.0005265732,0.002211136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004858141,"about_ca_system_score_gemma":0.0006800739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069526,"about_ca_topic_score_gemma":0.002974491,"domain_scores_codex":[0.9994456,0.0002559622,0.0000701588,0.00003216435,0.0001574146,0.0000387025],"domain_scores_gemma":[0.9986847,0.0004828075,0.0003027806,0.00005687967,0.0003292977,0.0001435477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002300089,0.0005884623,0.2690789,0.0009474129,0.0001050532,0.001296215,0.0002467152,0.00267355,0.01493771,0.001535652,0.04168911,0.6646012],"study_design_scores_gemma":[0.0006081637,0.002874909,0.7355846,0.001754147,0.0005922213,0.0078941,0.001927943,0.02539645,0.03757565,0.01098368,0.1746572,0.0001508577],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7160355,0.06780078,0.06770489,0.02087805,0.002035969,0.002578645,0.0123054,0.004157996,0.1065027],"genre_scores_gemma":[0.8549668,0.01053143,0.1165611,0.001799328,0.000645745,0.0008232486,0.005581868,0.0002021936,0.008888305],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.006372679,"threshold_uncertainty_score":0.02131879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07457581712649966,"score_gpt":0.4305560753139689,"score_spread":0.3559802581874693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}