{"id":"W4379285679","doi":"10.1200/jco.2023.41.16_suppl.1012","title":"BRACELET-1 (PrE0113): Inducing an inflammatory phenotype in metastatic HR+/HER2- breast cancer with the oncolytic reovirus pelareorep in combination with paclitaxel and avelumab.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"Oncolytics Biotech","keywords":"Medicine; Internal medicine; Clinical endpoint; Metastatic breast cancer; Oncology; Breast cancer; Cohort; Cancer; Everolimus; Progression-free survival; Response Evaluation Criteria in Solid Tumors; Progressive disease; Chemotherapy; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005647563,0.000845179,0.0009765141,0.0004128381,0.0001941437,0.0005912816,0.0007623193,0.0006527603,0.003567267],"category_scores_gemma":[0.0003321375,0.0003719571,0.0006878095,0.0004617799,0.0004718209,0.00040586,0.0002461939,0.001903429,0.0006151971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007263449,"about_ca_system_score_gemma":0.001189027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001167969,"about_ca_topic_score_gemma":0.003423581,"domain_scores_codex":[0.9998,0.00006581091,0.000009294692,0.00002431057,0.00002388925,0.00007671421],"domain_scores_gemma":[0.9998234,0.00003544916,0.00004032253,0.00001706051,0.000007634972,0.00007621771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3166755,0.09174304,0.004122414,0.001481399,0.0007493711,0.0004966052,0.0002191635,0.003228307,0.4165149,0.0006590493,0.007323904,0.1567864],"study_design_scores_gemma":[0.2371845,0.6497552,0.01500188,0.00007054982,0.0005233219,0.0008910261,0.00007231211,0.001692106,0.08771653,0.0001699,0.006875454,0.00004724333],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944021,0.001653005,0.0003601487,0.0002614279,0.0001379991,0.0007818034,0.0005706529,0.0001235548,0.001709324],"genre_scores_gemma":[0.9923299,0.001654005,0.001003936,0.0002862597,0.00009200965,0.000806561,0.001501515,0.0000231447,0.002302619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003567267,"threshold_uncertainty_score":0.01193374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05960428248022853,"score_gpt":0.4296832217146817,"score_spread":0.3700789392344532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}