{"id":"W4379285707","doi":"10.1200/jco.2023.41.16_suppl.1073","title":"Clinical outcomes and correlation with longitudinal circulating tumor (ct)DNA dynamics of a phase I/II study of GSK525762 combined with fulvestrant in patients with hormone receptor-positive/HER2-negative (HR+/HER2−) advanced or metastatic breast cancer.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ottawa Hospital; University Health Network","funders":"","keywords":"Medicine; Fulvestrant; Dysgeusia; Internal medicine; Pharmacodynamics; Oncology; Aromatase inhibitor; Metastatic breast cancer; Exemestane; Tolerability; Adverse effect; Cancer; Breast cancer; Pharmacology; Estrogen receptor; Pharmacokinetics; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00126332,0.0007223925,0.000995395,0.0003036101,0.0002156792,0.0005022352,0.0003614853,0.0006666349,0.001351172],"category_scores_gemma":[0.0009786624,0.000334125,0.0007864487,0.0003206304,0.000459147,0.0004396858,0.0002398542,0.001352519,0.0003890575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005587651,"about_ca_system_score_gemma":0.000554932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003752017,"about_ca_topic_score_gemma":0.0005631679,"domain_scores_codex":[0.9996432,0.0001452785,0.00002594696,0.00008121724,0.00004689417,0.00005730096],"domain_scores_gemma":[0.9990906,0.0001543962,0.0002570499,0.00006754113,0.00006188278,0.0003686135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6124297,0.04161457,0.1779345,0.0005686132,0.001771752,0.0004360416,0.0003618173,0.003444743,0.07174753,0.000110655,0.001347799,0.08823225],"study_design_scores_gemma":[0.06878291,0.6524565,0.2607879,0.00003265187,0.001302331,0.0006010867,0.0001025687,0.002469297,0.01118605,0.0001058302,0.002124621,0.00004828875],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980755,0.0007298016,0.000145603,0.00004335894,0.00001409093,0.0003092003,0.0002813758,0.00001280493,0.0003882445],"genre_scores_gemma":[0.9977411,0.0002754283,0.0002344777,0.0001128989,0.00002778239,0.0003477015,0.000809444,0.000005633433,0.0004454299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351172,"threshold_uncertainty_score":0.006681144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03716716879121391,"score_gpt":0.3931206851017177,"score_spread":0.3559535163105038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}