{"id":"W4379285726","doi":"10.1200/jco.2023.41.16_suppl.1075","title":"Impact of pathogenic germline <i>BRCA1/2</i> and <i>PALB2</i> mutations and tumor aneuploidy in patients with HR+/HER2- metastatic breast cancer treated with CDK4/6 inhibitors.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Palbociclib; Oncology; Breast cancer; Cancer; Internal medicine; Germline; Metastatic breast cancer; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003005754,0.00013392,0.0002270992,0.0002674323,0.0001440516,0.0003832892,0.0001425428,0.0002113277,0.000928116],"category_scores_gemma":[0.0008356582,0.0001052407,0.0001964691,0.0003258136,0.0001650661,0.0002010448,0.00016308,0.0002454046,0.0001236033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003249658,"about_ca_system_score_gemma":0.0002457324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001458406,"about_ca_topic_score_gemma":0.002021045,"domain_scores_codex":[0.9998691,0.00004176386,0.0000137129,0.00003307226,0.00002099898,0.00002138234],"domain_scores_gemma":[0.9995547,0.0001641355,0.0001637557,0.00001693883,0.00001642338,0.00008399515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001947117,0.00005237727,0.9903441,0.00001407951,0.00007626817,0.0003736003,0.00003719266,0.000324486,0.001602286,0.00001790358,0.0001375679,0.005073047],"study_design_scores_gemma":[0.00005091908,0.0008412171,0.9962735,0.000006370803,0.00009227265,0.001321289,0.0000693754,0.0006537188,0.0003986456,0.00003870337,0.0002506741,0.000003347149],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993917,0.0002225314,0.0000270993,0.00002082727,0.000001236547,0.000003244993,0.000109874,0.000001979913,0.0002215323],"genre_scores_gemma":[0.9997606,0.00004647443,0.00002330958,0.00001047282,0.000003103646,0.000001902736,0.0001186407,9.397658e-7,0.00003460095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001458406,"threshold_uncertainty_score":0.003104806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512793821252162,"score_gpt":0.4065957463143772,"score_spread":0.3714678081018555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}