{"id":"W4379285726","doi":"10.1200/jco.2023.41.16_suppl.1075","title":"Impact of pathogenic germline <i>BRCA1/2</i> and <i>PALB2</i> mutations and tumor aneuploidy in patients with HR+/HER2- metastatic breast cancer treated with CDK4/6 inhibitors.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Palbociclib; Oncology; Breast cancer; Cancer; Internal medicine; Germline; Metastatic breast cancer; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007998983,0.0002230197,0.00155218,0.0002831189,0.00003260363,0.000006868806,0.00007261672,0.0001037386,0.00004231837],"category_scores_gemma":[0.0002688723,0.00013019,0.0001530653,0.0006074347,0.000503435,0.0001997785,0.00003287453,0.0005657161,0.000001168338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645494,"about_ca_system_score_gemma":0.001101357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001742514,"about_ca_topic_score_gemma":0.0002423953,"domain_scores_codex":[0.9973376,0.0002400309,0.001522518,0.0002532927,0.0003596926,0.0002867984],"domain_scores_gemma":[0.9965444,0.0009027835,0.001463748,0.0001536212,0.0005894615,0.0003460285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01381199,0.00117785,0.9327366,0.00006783287,0.0006594931,0.0004640606,0.0001836068,0.0002696923,0.0003983004,0.00000206252,0.0000534075,0.05017507],"study_design_scores_gemma":[0.0236214,0.01470553,0.9594486,0.0003636346,0.0005462482,0.0007639756,0.0001285947,0.00006918872,0.0000333312,0.00004940153,0.0001420564,0.0001279876],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997875,0.0004141161,0.00001763275,0.001099386,0.0000829174,0.0003604746,0.0001166596,0.00001442007,0.00001933712],"genre_scores_gemma":[0.9979398,0.0003163981,0.001166837,0.0003204959,0.0001639904,0.00001420414,0.00001394626,0.00003886345,0.00002546856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05004708,"threshold_uncertainty_score":0.5308995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512793821252162,"score_gpt":0.4065957463143772,"score_spread":0.3714678081018555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}