{"id":"W4379285864","doi":"10.1200/jco.2023.41.16_suppl.tps1121","title":"TACTIVE-U: Phase 1b/2 umbrella study of ARV-471, a proteolysis targeting chimera (PROTAC) estrogen receptor (ER) degrader, combined with other anticancer treatments in ER+ advanced or metastatic breast cancer.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Fulvestrant; Metastatic breast cancer; Breast cancer; Internal medicine; Oncology; Cancer; Estrogen receptor; Palbociclib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001688487,0.0004138405,0.003174863,0.0004044314,0.00007172554,0.000009614931,0.000274517,0.0001828839,0.0003855373],"category_scores_gemma":[0.0007835898,0.0002564113,0.000365937,0.001228775,0.0003264082,0.0003090814,0.00006060113,0.000991637,0.000009997498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005189302,"about_ca_system_score_gemma":0.001908435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002121098,"about_ca_topic_score_gemma":0.0002265602,"domain_scores_codex":[0.9943423,0.0008368888,0.002966815,0.0005145624,0.0007692203,0.0005701834],"domain_scores_gemma":[0.9940577,0.001374149,0.003257406,0.0003463118,0.0005681425,0.0003962579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2322957,0.04240192,0.219044,0.0002343747,0.007242964,0.001389413,0.002203041,0.0008485672,0.008952607,0.00001419581,0.0001133238,0.4852599],"study_design_scores_gemma":[0.4707323,0.2252939,0.2639521,0.002834185,0.005719439,0.0009126097,0.01518205,0.0008722064,0.004602733,0.0002831889,0.008575032,0.00104018],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933914,0.0007995144,0.0001336596,0.002801672,0.0003691913,0.002357291,0.0000644959,0.00003619498,0.00004661124],"genre_scores_gemma":[0.9877301,0.001100204,0.0096775,0.0003632308,0.00038583,0.0003673818,0.000006877949,0.00009907159,0.0002697616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4842197,"threshold_uncertainty_score":0.9999888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1252189411704392,"score_gpt":0.496141122316609,"score_spread":0.3709221811461697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}