{"id":"W4379285864","doi":"10.1200/jco.2023.41.16_suppl.tps1121","title":"TACTIVE-U: Phase 1b/2 umbrella study of ARV-471, a proteolysis targeting chimera (PROTAC) estrogen receptor (ER) degrader, combined with other anticancer treatments in ER+ advanced or metastatic breast cancer.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Fulvestrant; Metastatic breast cancer; Breast cancer; Internal medicine; Oncology; Cancer; Estrogen receptor; Palbociclib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001737056,0.00141306,0.001071367,0.0006030466,0.0004456267,0.001266339,0.001191561,0.001678234,0.005998271],"category_scores_gemma":[0.0005774241,0.000548444,0.001133748,0.0005110884,0.0007463241,0.0009162963,0.0003643889,0.003168633,0.001734546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001451707,"about_ca_system_score_gemma":0.001437634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001552824,"about_ca_topic_score_gemma":0.004860661,"domain_scores_codex":[0.9995049,0.0002338342,0.00001879641,0.0000781294,0.0000642857,0.00009991873],"domain_scores_gemma":[0.9995565,0.00004189487,0.000102684,0.00005711334,0.00002820575,0.0002134936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.285866,0.1275428,0.007044776,0.001418513,0.002021841,0.0006307316,0.0003984311,0.00354533,0.3022853,0.001589612,0.02649629,0.2411604],"study_design_scores_gemma":[0.2580231,0.6120457,0.01967788,0.0001380316,0.00132056,0.002400545,0.0001842524,0.003242971,0.06754464,0.0005737123,0.03476254,0.00008598027],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9653409,0.009260565,0.002608373,0.001229023,0.0003161056,0.005043672,0.005468243,0.0005531331,0.01017998],"genre_scores_gemma":[0.9574805,0.005276121,0.006048891,0.002321245,0.0002914248,0.004906773,0.01156717,0.0001337244,0.01197412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005998271,"threshold_uncertainty_score":0.02006626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1252189411704392,"score_gpt":0.496141122316609,"score_spread":0.3709221811461697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}