{"id":"W4379329068","doi":"10.1200/jco.2023.41.16_suppl.1078","title":"Alpelisib + endocrine therapy in patients with <i>PIK3CA</i>-mutated, hormone receptor–positive, human epidermal growth factor receptor 2–negative, advanced breast cancer: Analysis of all 3 cohorts of the BYLieve study.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Letrozole; Fulvestrant; Internal medicine; Tolerability; Breast cancer; Cohort; Oncology; Cancer; Metastatic breast cancer; Adverse effect; Gynecology; Aromatase; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001553232,0.0005726175,0.001095445,0.0003340027,0.0001865894,0.0008163226,0.0004592974,0.0004597865,0.001300007],"category_scores_gemma":[0.0006988156,0.0002680498,0.001325531,0.0004490521,0.0003141137,0.0005639451,0.000437363,0.0009663501,0.0003056722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000498668,"about_ca_system_score_gemma":0.0006331526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006285719,"about_ca_topic_score_gemma":0.00181786,"domain_scores_codex":[0.9994832,0.0002427386,0.00002372686,0.00009709649,0.00007508053,0.00007807744],"domain_scores_gemma":[0.9993692,0.0001219749,0.0001934589,0.00008046913,0.00004990775,0.0001849277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5951155,0.006980747,0.3037091,0.0006711837,0.005799486,0.0002045509,0.0002738902,0.001387638,0.01447696,0.000293358,0.003472774,0.0676147],"study_design_scores_gemma":[0.1281115,0.1986042,0.6430846,0.0001876967,0.005281494,0.001575753,0.0003768823,0.002104922,0.004870602,0.0006620188,0.01504979,0.00009065442],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961998,0.001697237,0.0001200726,0.00006201692,0.00001550138,0.0001746189,0.0009268009,0.00001370353,0.0007902571],"genre_scores_gemma":[0.9919626,0.0009195824,0.0003346777,0.0002693434,0.00005284354,0.0002845194,0.005468606,0.00001229345,0.0006955324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553232,"threshold_uncertainty_score":0.008214414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0445158908315171,"score_gpt":0.4085474749493247,"score_spread":0.3640315841178076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}