{"id":"W4379332762","doi":"10.1200/jco.2023.41.16_suppl.4073","title":"Temporal patterns of immune-mediated adverse events (imAEs) with tremelimumab (T) plus durvalumab (D) in the phase 3 HIMALAYA study in unresectable hepatocellular carcinoma (uHCC).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; STRIDE; Regimen; Adverse effect; Internal medicine; Oncology; Surgery; Gastroenterology; Physical medicine and rehabilitation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002296717,0.0001824544,0.0003228699,0.0003487309,0.0001972027,0.0004038121,0.0002177978,0.0001719423,0.001258094],"category_scores_gemma":[0.002124474,0.0001517409,0.000792111,0.000464807,0.0001696505,0.0002923782,0.0003557461,0.0004427687,0.0001261719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004033944,"about_ca_system_score_gemma":0.0003645082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008028272,"about_ca_topic_score_gemma":0.002124903,"domain_scores_codex":[0.9989864,0.0004339001,0.0001214017,0.0001606081,0.0002066238,0.0000911004],"domain_scores_gemma":[0.9970027,0.0006852376,0.001737655,0.0001864654,0.0001576597,0.000230298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.04996528,0.0006428224,0.8993461,0.0004036439,0.00283787,0.0003556239,0.0002627458,0.001164967,0.00541005,0.0001006907,0.0009364059,0.03857385],"study_design_scores_gemma":[0.0009910208,0.005500852,0.9887672,0.00002556982,0.000698373,0.0006450443,0.0001195464,0.00105211,0.001229845,0.00008379968,0.000867829,0.00001875834],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979571,0.0008409981,0.0001794093,0.00003432971,0.000004151711,0.00005995412,0.0005613767,0.00000621231,0.0003564333],"genre_scores_gemma":[0.999076,0.0001624284,0.0001236544,0.00003350384,0.000007783909,0.00003564061,0.0004376301,0.000002096342,0.0001212974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002296717,"threshold_uncertainty_score":0.01214635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1177484084608746,"score_gpt":0.437047860020373,"score_spread":0.3192994515594985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}