{"id":"W4379333138","doi":"10.1200/jco.2023.41.16_suppl.5503","title":"Dostarlimab for primary advanced or recurrent (A/R) endometrial cancer (EC): Outcomes by blinded independent central review (BICR) of the RUBY trial (ENGOT-EN6-NSGO/GOG-3031/RUBY).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Clinical endpoint; Internal medicine; Carboplatin; Endometrial cancer; Microsatellite instability; Oncology; Paclitaxel; Placebo; Randomized controlled trial; Progression-free survival; Cancer; Overall survival; Gynecology; Chemotherapy; Cisplatin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01633714,0.001161678,0.002832994,0.0006168284,0.0006263157,0.001444884,0.0009797744,0.001785976,0.005451518],"category_scores_gemma":[0.01120115,0.0006599246,0.002123104,0.0007730386,0.000805212,0.0009710861,0.0008281885,0.001450446,0.0009054056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001343136,"about_ca_system_score_gemma":0.002688327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001221013,"about_ca_topic_score_gemma":0.003058207,"domain_scores_codex":[0.9911011,0.006958558,0.00052465,0.0006751522,0.0004912212,0.0002492459],"domain_scores_gemma":[0.9934483,0.001579587,0.003014265,0.0006563026,0.0006819533,0.0006196374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9229907,0.001086347,0.004714033,0.008132257,0.006582974,0.0000406678,0.0001652898,0.0003001363,0.002446114,0.000217508,0.006743546,0.04658041],"study_design_scores_gemma":[0.93015,0.02787356,0.02158181,0.0009025106,0.00746997,0.0001370052,0.0000513088,0.0006313098,0.001015344,0.0003998718,0.009732438,0.00005494671],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7967439,0.09839412,0.003542587,0.002615737,0.001090339,0.06528737,0.01908603,0.0004868126,0.01275303],"genre_scores_gemma":[0.9511189,0.008823941,0.004664873,0.001774428,0.0006118714,0.02444925,0.005770472,0.00009138553,0.002694828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01633714,"threshold_uncertainty_score":0.08640009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.114559920450182,"score_gpt":0.4671512227419978,"score_spread":0.3525913022918158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}