{"id":"W4379334471","doi":"10.1200/jco.2023.41.16_suppl.3540","title":"Does serial circulating tumor DNA (ctDNA) monitoring identify additional acquired actionable alterations in metastatic colorectal cancer (mCRC)?","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Indel; KRAS; Colorectal cancer; Medicine; Neuroblastoma RAS viral oncogene homolog; Somatic cell; Microsatellite instability; Cancer research; Liquid biopsy; Oncology; Genotype; V600E; Circulating tumor DNA; Cancer; Mutation; Internal medicine; Allele; Single-nucleotide polymorphism; Biology; Genetics; Gene; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008967261,0.000218063,0.0003671064,0.0006797878,0.0001198812,0.0005066224,0.0002380419,0.0004487218,0.0008725326],"category_scores_gemma":[0.004249748,0.0001395472,0.0002204957,0.0006766014,0.000268813,0.0004271694,0.0001721677,0.0002425913,0.0002504447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003196375,"about_ca_system_score_gemma":0.0002647965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00197675,"about_ca_topic_score_gemma":0.002922649,"domain_scores_codex":[0.999575,0.00008960266,0.00006210373,0.00009928256,0.0001268173,0.00004728222],"domain_scores_gemma":[0.9977398,0.0006707747,0.0009202348,0.0001095997,0.0003106043,0.0002490967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003665267,0.00001260344,0.9917518,0.00002004897,0.00001559937,0.0001150891,0.00001772157,0.00007951275,0.0009187415,0.00001102411,0.00008702273,0.006604343],"study_design_scores_gemma":[0.00002634076,0.0009471303,0.9920614,0.00003214877,0.00007661604,0.002479873,0.00009600259,0.001446039,0.00180476,0.00006447449,0.0009588579,0.000006386037],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969439,0.00171741,0.000358145,0.0001384557,0.00001259863,0.00001279278,0.0002745511,0.00001083949,0.0005311978],"genre_scores_gemma":[0.9991098,0.0002708433,0.0002976039,0.00004874963,0.00001584579,0.000002879421,0.0001855046,0.000002195535,0.00006659759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00197675,"threshold_uncertainty_score":0.004742384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0744419537187974,"score_gpt":0.4355758523876607,"score_spread":0.3611338986688633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}