{"id":"W4379335699","doi":"10.1200/jco.2023.41.16_suppl.tps4609","title":"MAIN-CAV: Phase III randomized trial of maintenance cabozantinib and avelumab versus avelumab after first-line platinum-based chemotherapy in patients (pts) with metastatic urothelial cancer (mUC; Alliance A032001).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institutes of Health","keywords":"Medicine; Avelumab; Chemotherapy; Internal medicine; Oncology; Maintenance therapy; Cabozantinib; Cancer; Surgery; Immunotherapy; Pembrolizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001937804,0.002106556,0.002321498,0.0003810633,0.0003503167,0.001234346,0.001337167,0.001925588,0.01071878],"category_scores_gemma":[0.001690048,0.0007727164,0.001821793,0.0003973134,0.001168298,0.001206005,0.0005386208,0.003718112,0.001682303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001033694,"about_ca_system_score_gemma":0.001569923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001313104,"about_ca_topic_score_gemma":0.003273563,"domain_scores_codex":[0.9995203,0.0002475068,0.00002329151,0.00008475668,0.00003192745,0.00009223021],"domain_scores_gemma":[0.9990302,0.0001978917,0.0002339783,0.00006655818,0.00005303679,0.0004183531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9788285,0.005669223,0.0005545948,0.0004037337,0.0004703875,0.00002631984,0.00002822471,0.000334829,0.002440649,0.0001152161,0.001632929,0.009495479],"study_design_scores_gemma":[0.9367672,0.06020866,0.001185811,0.00002514867,0.0002504214,0.00003728171,0.00001474109,0.0004059735,0.0002669133,0.0001402024,0.000689636,0.0000080588],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733772,0.006504708,0.00089983,0.001914677,0.001063398,0.007453688,0.003719971,0.0003974661,0.00466909],"genre_scores_gemma":[0.9718274,0.002807851,0.002596163,0.002370873,0.0007703525,0.008051047,0.003843686,0.00007300632,0.007659626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01071878,"threshold_uncertainty_score":0.03585792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07253974970556581,"score_gpt":0.4313328218838253,"score_spread":0.3587930721782595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}