{"id":"W4379336150","doi":"10.1200/jco.2023.41.16_suppl.tps5630","title":"Randomized phase III trial in MMR deficient (MMRd) endometrial cancer (EC) patients comparing chemotherapy (CT) alone versus dostarlimab in first line advanced/metastatic setting: DOMENICA study (GINECO-EN105b/ENGOT-en13 study).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Carboplatin; Endometrial cancer; Clinical endpoint; Internal medicine; Oncology; Randomized controlled trial; Chemotherapy; Radiation therapy; Cancer; Paclitaxel; Surgery; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002534035,0.001587152,0.002228912,0.0003475205,0.0003397582,0.0009453794,0.001041329,0.00169627,0.006305428],"category_scores_gemma":[0.001668352,0.0005997199,0.001593644,0.000378988,0.000818502,0.0008508227,0.000593683,0.00324212,0.001094923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009061301,"about_ca_system_score_gemma":0.001118229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00096025,"about_ca_topic_score_gemma":0.003012972,"domain_scores_codex":[0.9994912,0.0003132026,0.00001849045,0.00007825219,0.00002542806,0.00007348309],"domain_scores_gemma":[0.9991626,0.0001644913,0.0001824349,0.00007975139,0.00004495411,0.0003658299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9703127,0.006510426,0.001551583,0.0004526671,0.000736114,0.00004781749,0.00004211235,0.000534017,0.003654073,0.0001903407,0.002156615,0.0138117],"study_design_scores_gemma":[0.9437519,0.04973578,0.003264681,0.00003759122,0.0004222484,0.00007540343,0.00001906068,0.0004268138,0.0003616194,0.0002747198,0.001618059,0.00001212913],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678823,0.00748093,0.001166643,0.002550553,0.000996621,0.009374915,0.005139756,0.0001886287,0.005219555],"genre_scores_gemma":[0.9630908,0.003102729,0.004533173,0.004438825,0.0004782032,0.009553243,0.006825579,0.00006486767,0.007912526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006305428,"threshold_uncertainty_score":0.02109373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1695154486478239,"score_gpt":0.4998880469964148,"score_spread":0.3303725983485908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}