{"id":"W4379337128","doi":"10.1200/jco.2023.41.16_suppl.tps7088","title":"EXCEED-ET: A single-arm multicenter study to assess the efficacy, safety, and tolerability of ropeginterferon alfa-2b-njft (P1101) in North American adults with essential thrombocythemia.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Essential thrombocythemia; Tolerability; Anagrelide; Myelofibrosis; Thrombocytosis; Internal medicine; Polycythemia vera; Interferon alfa; Myeloproliferative neoplasm; Oncology; Alpha interferon; Surgery; Gastroenterology; Immunology; Bone marrow; Adverse effect; Platelet; Interferon","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002438361,0.001522025,0.00195233,0.0003129847,0.0004886406,0.0007018132,0.0006862744,0.001368674,0.00298014],"category_scores_gemma":[0.001320693,0.0005942879,0.00124526,0.0003217207,0.0009842827,0.001085564,0.0005443614,0.001732397,0.0006641694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007801236,"about_ca_system_score_gemma":0.001286607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008213256,"about_ca_topic_score_gemma":0.001893195,"domain_scores_codex":[0.9991033,0.0004829787,0.00005573254,0.0001512371,0.00008292712,0.0001238706],"domain_scores_gemma":[0.998239,0.0002164117,0.0004533811,0.0001590824,0.0001092075,0.0008228555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8747353,0.06164911,0.01909147,0.0003763736,0.001602178,0.0001872639,0.0002873301,0.0006918032,0.01232065,0.0001037959,0.00110894,0.02784575],"study_design_scores_gemma":[0.4159798,0.5266041,0.05283074,0.00002602695,0.0008066051,0.0002802772,0.0001117168,0.0008014909,0.001009693,0.0001131737,0.001396809,0.00003965836],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997045,0.0005689217,0.0002600824,0.0001507122,0.000038417,0.001119453,0.0003585297,0.00003820997,0.0004206016],"genre_scores_gemma":[0.9930732,0.0004497189,0.001268188,0.0005446547,0.0001661882,0.002626864,0.0008710847,0.00001423355,0.0009858768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00298014,"threshold_uncertainty_score":0.01289546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1060222985872446,"score_gpt":0.4481146316255874,"score_spread":0.3420923330383427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}