{"id":"W4379337241","doi":"10.1200/jco.2023.41.16_suppl.4555","title":"Impact of smoking status (SS) on the clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) treated with first line (1L) immuno-oncology (IO)-combination regimens: Results from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; McMaster University; Cancer Care Ontario; Dalhousie University; Queen Elizabeth II Health Sciences Centre; University of Alberta; University of Calgary; BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Renal cell carcinoma; Oncology; Proportional hazards model; Pembrolizumab; Logistic regression; Lung cancer; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009782088,0.0001432219,0.0003361915,0.0005374572,0.0001815193,0.0006901826,0.0003376054,0.0003184191,0.001080944],"category_scores_gemma":[0.002614058,0.0001300613,0.0006053244,0.0009150574,0.0001592895,0.000342391,0.0004705081,0.0003498534,0.0002022495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004237571,"about_ca_system_score_gemma":0.0002937655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003971419,"about_ca_topic_score_gemma":0.007029067,"domain_scores_codex":[0.999361,0.0001912004,0.00009831374,0.0001278377,0.0001509829,0.00007075116],"domain_scores_gemma":[0.9972078,0.0005869221,0.001576002,0.0001538695,0.0002069558,0.0002684876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004064419,0.00002307579,0.997801,0.0000187401,0.00009062165,0.00001556157,0.00001355079,0.00004103696,0.00006117411,0.000007195376,0.0001029551,0.001418546],"study_design_scores_gemma":[0.00002019916,0.0001394618,0.9991098,0.00000980523,0.00008268017,0.00009850486,0.00003306253,0.000202024,0.00004375547,0.000008900883,0.00024877,0.000002896495],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956836,0.0007435536,0.00005248724,0.00004962781,0.000004938657,0.00001532158,0.003070822,0.000002714383,0.0003770192],"genre_scores_gemma":[0.9971903,0.0001671646,0.00004450562,0.00002798406,0.000009929401,0.0000112532,0.002459941,0.000001175505,0.00008770428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003971419,"threshold_uncertainty_score":0.007896602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1260057301905067,"score_gpt":0.4047002711503722,"score_spread":0.2786945409598655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}