{"id":"W4379339399","doi":"10.1200/jco.2023.41.16_suppl.11567","title":"Immune correlates of outcome in patients with leiomyosarcoma (LMS) treated with durvalumab plus olaparib or cediranib: Transcriptome analysis from the DAPPER study.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"University Health Network","keywords":"Olaparib; Medicine; Oncology; PARP inhibitor; Internal medicine; Proportional hazards model; Transcriptome; Immune checkpoint; Immune system; Response Evaluation Criteria in Solid Tumors; Progression-free survival; Hazard ratio; Cohort; Biomarker; Bevacizumab; Cancer research; Progressive disease; Immunotherapy; Cancer; Immunology; Disease; Chemotherapy; Poly ADP ribose polymerase; Biology; Overall survival; Confidence interval; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000237042,0.0001606772,0.000340994,0.0002007106,0.0001147777,0.0003274619,0.0001175724,0.0001560858,0.0006622786],"category_scores_gemma":[0.0003687055,0.00009702247,0.0002485818,0.0003000025,0.0001089607,0.0001151048,0.0001906633,0.0002394621,0.0001398095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001809654,"about_ca_system_score_gemma":0.0001251835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004259696,"about_ca_topic_score_gemma":0.0007764798,"domain_scores_codex":[0.9999056,0.00002918567,0.000006536769,0.00002538228,0.00001569654,0.00001753081],"domain_scores_gemma":[0.9998549,0.00003442157,0.0000494895,0.00001113417,0.00001095956,0.00003901413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0149426,0.000327363,0.9416994,0.00009162355,0.0005193432,0.0004487615,0.0001319619,0.0004515891,0.02247364,0.00004726972,0.0008703062,0.01799611],"study_design_scores_gemma":[0.0002621647,0.001384944,0.9957495,0.000006780496,0.0001987581,0.0003724919,0.00009474994,0.000599438,0.0007340756,0.00004280806,0.0005487836,0.000005537992],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999281,0.0002201037,0.00005129219,0.00002245796,0.000002593265,0.000006548042,0.0003083052,0.000001763252,0.0001058493],"genre_scores_gemma":[0.9985618,0.00009085879,0.00009477961,0.00004310533,0.000008659902,0.00001336844,0.00109916,0.000001448871,0.00008673585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006622786,"threshold_uncertainty_score":0.002215505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09993577892613789,"score_gpt":0.4124282723606569,"score_spread":0.312492493434519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}