{"id":"W4379339637","doi":"10.1200/jco.2023.41.16_suppl.e21506","title":"Patient characteristics and treatment patterns in BRAF-mutated unresectable or metastatic melanoma in the United States: A snapshot from real-world data.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"Pfizer","keywords":"Medicine; Ipilimumab; Melanoma; Dabrafenib; Trametinib; Internal medicine; Nivolumab; Oncology; Metastatic melanoma; Targeted therapy; Retrospective cohort study; Gastroenterology; Vemurafenib; Cancer; Cancer research; Immunotherapy; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006498345,0.0001447692,0.0002738522,0.001278759,0.0002599781,0.0005274211,0.0002831314,0.000317639,0.001628889],"category_scores_gemma":[0.001816125,0.0001857199,0.0003922416,0.00244761,0.0001629204,0.0005880859,0.0004405481,0.0004493825,0.0002976308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006128589,"about_ca_system_score_gemma":0.0005466619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0124336,"about_ca_topic_score_gemma":0.0214381,"domain_scores_codex":[0.9993644,0.0001352104,0.0001488712,0.0001567804,0.00009289549,0.0001017599],"domain_scores_gemma":[0.9975296,0.000345678,0.001530726,0.00008014808,0.0002599238,0.000254049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007785854,0.00002539555,0.9972278,0.00003150372,0.00003418574,0.00005011287,0.00005756301,0.00004477269,0.00005671026,0.00001726717,0.000715499,0.001661244],"study_design_scores_gemma":[0.000005803513,0.0000586384,0.9981276,0.00003091718,0.00001987251,0.000276897,0.000418973,0.0001655043,0.0000453319,0.0000131345,0.000832563,0.000004752349],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824332,0.001427551,0.0001128501,0.0002640978,0.00001057954,0.0000279663,0.01488893,0.0000119977,0.000822849],"genre_scores_gemma":[0.9901775,0.0006895752,0.0001697248,0.0001466802,0.00001356644,0.00003235148,0.008600038,0.00000434609,0.0001661943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0124336,"threshold_uncertainty_score":0.02472246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2015642610219666,"score_gpt":0.4412286672724616,"score_spread":0.239664406250495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}