{"id":"W4379341825","doi":"10.1200/jco.2023.41.16_suppl.tps8611","title":"Randomized phase 3 study of tarlatamab, a DLL3-targeting bispecific T-cell engager (BiTE),compared to standard of care in patients with relapsed small cell lung cancer (DeLLphi-304).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Amgen","keywords":"Topotecan; Medicine; Refractory (planetary science); Internal medicine; Discontinuation; Oncology; Chemotherapy; Lung cancer; Cancer; Malignancy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00175464,0.001791935,0.002540068,0.0003910411,0.0004500105,0.001421178,0.0009265212,0.001813066,0.009844058],"category_scores_gemma":[0.001524743,0.000744579,0.001897255,0.0003781039,0.001116652,0.00129669,0.000463552,0.004902313,0.001558682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001286565,"about_ca_system_score_gemma":0.001498758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001244437,"about_ca_topic_score_gemma":0.003068781,"domain_scores_codex":[0.9994561,0.0002503373,0.00002611118,0.0001091535,0.00004114562,0.0001171971],"domain_scores_gemma":[0.9989195,0.0002838533,0.0002008823,0.00008579287,0.00007728529,0.0004327293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9638754,0.01481228,0.0006735177,0.0003445871,0.0007032449,0.00004810108,0.00005395271,0.0004496961,0.003449562,0.0001227462,0.001420545,0.01404639],"study_design_scores_gemma":[0.8097417,0.1859576,0.001754808,0.00002287246,0.0002953041,0.00005666195,0.00002897528,0.0005315884,0.0004487233,0.0002266199,0.0009174135,0.00001776367],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812221,0.002751765,0.0007230272,0.0009874969,0.0007180282,0.007131009,0.002603777,0.0002062922,0.003656537],"genre_scores_gemma":[0.981499,0.001447567,0.001562369,0.001788438,0.0003750436,0.006694409,0.002521425,0.00004817499,0.00406365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009844058,"threshold_uncertainty_score":0.03293169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08975948839399366,"score_gpt":0.4811738018165464,"score_spread":0.3914143134225527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}