{"id":"W4379341825","doi":"10.1200/jco.2023.41.16_suppl.tps8611","title":"Randomized phase 3 study of tarlatamab, a DLL3-targeting bispecific T-cell engager (BiTE),compared to standard of care in patients with relapsed small cell lung cancer (DeLLphi-304).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Amgen","keywords":"Topotecan; Medicine; Refractory (planetary science); Internal medicine; Discontinuation; Oncology; Chemotherapy; Lung cancer; Cancer; Malignancy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008313868,0.0002618189,0.004595212,0.0005676135,0.00006194049,0.00000789084,0.0003214071,0.0002021099,0.0001038367],"category_scores_gemma":[0.005822534,0.0001704505,0.000455223,0.0009062198,0.0002611074,0.00008023535,0.0001996292,0.001554213,0.000003227581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005547925,"about_ca_system_score_gemma":0.002161297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001955067,"about_ca_topic_score_gemma":0.0004913763,"domain_scores_codex":[0.9917106,0.002092782,0.004083272,0.0003843698,0.001240926,0.0004880409],"domain_scores_gemma":[0.9887682,0.005757819,0.002474966,0.0003360585,0.002243391,0.0004195871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6427338,0.005627542,0.3321461,0.0005684929,0.0008313057,0.0004052279,0.009208512,0.0009185466,0.0002883607,8.363341e-7,0.004613955,0.002657364],"study_design_scores_gemma":[0.8691561,0.05605631,0.05905706,0.0008316616,0.001106004,0.000001461865,0.01027512,0.0001861197,0.0007001149,0.000006193688,0.002415618,0.0002082798],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933936,0.001874845,0.00002688571,0.0007309006,0.0006840175,0.002728438,0.00004835307,0.00001402031,0.000498965],"genre_scores_gemma":[0.9973742,0.0009075171,0.001045836,0.0001176329,0.0003023889,0.0000667885,0.00001037714,0.00004258648,0.0001326221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2730891,"threshold_uncertainty_score":0.6970537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08975948839399366,"score_gpt":0.4811738018165464,"score_spread":0.3914143134225527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}