{"id":"W4379364758","doi":"10.1038/s41392-023-01431-6","title":"CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors","year":2023,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China-Yunnan Joint Fund; National Natural Science Foundation of China","keywords":"Transmembrane domain; Amyloid precursor protein; Transmembrane protein; Neuroscience; Biology; Prefrontal cortex; Cell biology; Gene; Genetics; Receptor; Medicine; Internal medicine; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008380826,0.0003973163,0.0003297583,0.0002337638,0.000093892,0.0002074683,0.0002364956,0.000384764,0.001378948],"category_scores_gemma":[0.0001193073,0.0001049949,0.0002105923,0.0000888661,0.0002220504,0.0002096943,0.0001596943,0.0007388505,0.0002345219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002396137,"about_ca_system_score_gemma":0.0001932522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006692858,"about_ca_topic_score_gemma":0.0008771042,"domain_scores_codex":[0.9999127,0.000008871377,0.00001034731,0.00002537407,0.00002588334,0.00001679089],"domain_scores_gemma":[0.9999186,0.000007538338,0.00001942764,0.00000975539,0.00001034957,0.00003429158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002940073,0.0001083141,0.0001109622,0.0000440624,0.00001172347,0.00006517492,0.000009112191,0.00004559512,0.9973738,0.0000503542,0.00007326772,0.001813581],"study_design_scores_gemma":[0.0001705382,0.002092404,0.005274527,0.00001507864,0.00005907164,0.0005391653,0.00004902061,0.001239179,0.9864049,0.00009319465,0.004054986,0.000008031334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950908,0.001323187,0.001466546,0.0001332268,0.00006653433,0.00005397526,0.0004570213,0.000111823,0.001296794],"genre_scores_gemma":[0.994833,0.0007111842,0.001141857,0.00008561277,0.00001188387,0.00004937354,0.000603809,0.00001614341,0.002547096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001378948,"threshold_uncertainty_score":0.004613042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02091473214823582,"score_gpt":0.2650233299637968,"score_spread":0.244108597815561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}