{"id":"W4379365438","doi":"10.1016/j.chom.2023.05.011","title":"Gut bacterial metabolism contributes to host global purine homeostasis","year":2023,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Metabolomics Innovation Centre; National Institutes of Health; Novo Nordisk Fonden; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Riksförbundet HjärtLung; Hjärt-Lungfonden; Fondation Leducq; Knut och Alice Wallenbergs Stiftelse; AFA Försäkring","keywords":"Biology; Purine metabolism; Purine; Bacteria; Gut flora; Catabolism; Uric acid; Microbial metabolism; Microbiology; Homeostasis; Host (biology); Metabolism; Biochemistry; Cell biology; Genetics; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000199297,0.0002855818,0.0003307164,0.00008385124,0.0001654607,0.0000835031,0.0003627115,0.0002424283,0.0001341572],"category_scores_gemma":[0.00004639987,0.0002874153,0.0001549957,0.0004463688,0.00006919562,0.000004668013,0.0004413622,0.0001017464,0.001079133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004927582,"about_ca_system_score_gemma":0.0001736379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001163196,"about_ca_topic_score_gemma":0.0001253376,"domain_scores_codex":[0.9982359,0.00006152317,0.0003188586,0.0005813354,0.00008586433,0.0007165053],"domain_scores_gemma":[0.9990421,0.00001031632,0.00008133965,0.0005034437,0.0001296495,0.0002331833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001197927,0.0000600145,0.0004968658,0.000037817,0.0000392779,0.000009167919,0.00003207591,0.000001537459,0.8829043,0.00004115919,0.1157435,0.0005145138],"study_design_scores_gemma":[0.0008014506,0.00008468754,0.03317314,0.00001040682,0.00002675482,0.000008160845,0.00003806569,3.488955e-7,0.4530044,0.000007213652,0.5126352,0.0002100954],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923192,0.002515045,0.0001014484,0.001507522,0.001148724,0.0004442089,0.001059968,0.00006956685,0.0008342721],"genre_scores_gemma":[0.9912162,0.001089901,0.0004517157,0.002124209,0.0006951327,0.00003038004,0.001388555,0.00004926437,0.002954683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4298998,"threshold_uncertainty_score":0.9999578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007478646978331785,"score_gpt":0.2546134888603626,"score_spread":0.2471348418820308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}